TAC1

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TAC1

A gene on chromosome 7q21-q22 that encodes four different tachykinins—substance P, neurokinin A, neuropeptide K and neuropeptide gamma—which are thought to function as neurotransmitters, interacting with nerve receptors and smooth muscle cells, inducing behavioural responses and acting as vasodilators and secretagogues.
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For isolating single CTCs, we applied a micromanipulator consisting of the microinjector CellTram vario and the micromanipulator TransferMan NK2 (both Eppendorf) supplemented with custom-made capillaries (40 [micro]mol/L in diameter, capillary type III, Eppendorf) and connected to an Axiovert 200 inverted fluorescence microscope (Carl Zeiss).
Results from two phase III studies evaluating the NK2 receptor antagonist saredutant in major depressive disorders are expected in the second quarter of 2008.
Saredutant (SR48968) is a NK2 receptor antagonist in phase III for the treatment of Major Depressive Disorder (MDD) and General Anxiety Disorder (GAD).