NFATC2

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NFATC2

A gene on 20q13.2 that encodes a member of the nuclear factor of activated T cells (NFAT) family, which is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). NFATC2 is present in the cytosol and translocates to the nucleus after T-cell receptor (TCR) stimulation where it becomes a member of the NFAT transcription complex, which plays a central role in inducing gene transcription during the immune response.
References in periodicals archive ?
With respect to multisite phosphorylation or dephosphorylation, pathway simulation predicted that activation of transcription factor NFAT1 (nuclear factor of activated T cells) is ultrasensitive with a threshold (Salazar and Hofer 2003).
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.
Allosteric regulation of the transcription factor NFAT1 by multiple phosphorylation sites: a mathematical analysis.
We measured the inhibition of NFAT1 nuclear translocation, the intracellular expression of IL-2 in [CD4.
cells were studied as a function of NFAT1 expression by use of a large variety of models classically used for enzyme inhibition or receptor response, as well as simpler linear and nonlinear regression models.
The mean fluorescence intensity of PBMC nuclei expressing NFAT1 after ex vivo incubation with stimulants clearly showed the inhibitory effect of TAC.
NFAT1 in PBMC nuclei, as well as IL-2 and CD25 responses in each T cell subpopulation, were adequately fitted by I/[I.
Comparing normal mice with those genetically engineered to be incapable of making NFAT1 (Nuclear Factor of Activated T-cells-1), scientists were surprised to discover that the substance works in normal mice to moderate inflammation of the lungs during what, in people, would resemble an attack of asthma.
Xanthoudakis has co-headed the collaborative study of NFAT1 since its discovery by the Harvard group in 1993.
Just how NFAT1 works to moderate inflammation remains a mystery," said Dr.
The NFAT (formally NFATc) family consists of several members: NFAT1 (NFATp, NFATc2), NFAT2 (NFATc, NFATc1), NFAT3 (NFATc4), NFAT4 (NFATx, NFATc3), and NFAT5.
Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.