And when she's not busy studying at the University of the West of Scotland, she reaches out to other NF2
sufferers by working with UK-wide support group Can You Hear Us?
The team discovered the YAP-NF2
link by studying mice that had been genetically altered so that their livers were missing the NF2
is associated with tumours of the Schwann cells and meninges.
I've tried to put a brave face on things but as soon as I was told Yvonne had NF2
I knew she was going to die.
patients, the faulty gene on chromosome 22 is inherited.
Children's Tumor Foundation The Children's Tumor Foundation is a 501(c)(3) not-for-profit organization dedicated to finding effective treatments for the millions of people worldwide living with neurofibromatosis (NF), a term for three distinct disorders: NF1, NF2
, and schwannomatosis.
YAP1 has also been implicated in other cancers, he said, including lung and ovarian malignancies, and the mutation in NF2
has been found in other, less common forms of brain cancers as well as in mesothelioma, a type of lung cancer mostly associated with exposure to asbestos.
(neurofibromatosis 2) TSG, located on 22q12, was one of the first TSGs shown to be inactivated in MPM.
The quintessential neurologic finding of NF2
is bilateral vestibular nerve schwannomas.
The Foundation is dedicated to improving the health and well-being of the millions of people worldwide living with neurofibromatosis (NF), a term for three distinct disorders: NF1, NF2
Evaluation of NF2
and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: a study of 20 cases.
Studies conducted in the past have suggested that a particular tumour-suppressing gene on human chromosome 22, known as NF2
, may be a possible contributor to meningioma.