NF1


Also found in: Acronyms.

NF1

a gene associated with neurofibromatosis. The gene is normally part of a family that helps regulate the timing of cell divisions. It may become defective, leading to neurofibromatosis expression, when an itinerant sequence of a deoxyribonucleic acid molecule becomes wedged in the NF1 gene.

NF1

A gene on chromosome 17q11.2 that encodes neurofibromin 1, a protein which stimulates GTPase activity of Ras and may regulate Ras activity.

Molecular pathology
NF1 defects cause:
• Familial spinal neurofibromatosis;
• Juvenile myelomonocytic leukaemia;
• Neurofibromatosis type 1;
• Neurofibromatosis-Noonan syndrome;
• Watson syndrome; and
• Some cases of colorectal carcinoma.
References in periodicals archive ?
I believe NF1 and osteosarcoma are results of fluoride toxicity which causes a rather newly recognized disease, called hypothyroidism 2.
David, who's worked with NF1 charity Funny Lumps, said: "This meant more surgery followed by 18 months of chemotherapy to shrink the growth and prevent it becoming malignant.
Women with NF1 were almost three times more likely to develop preeclampsia than were controls (odds ratio, 2.
Devoted Samantha, who has non-malignant NF1 herself, has been by Abigail's side every step of the way.
2009) Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.
NF1 has variable expressivity and does not run true within a family.
Biz de davranis degisiklikleri ve bilinc bozulmasi ile gelen, EEG ile tanisi kesinlestirilmis bir nonkonvulzif statuslu hastanin Jaffe Campanacci sendromu birlikteligini ve NF1 ile benzerligini sunmaya deger bulduk.
The FN MAG 58 was pitted against the M60E2, M219 (for control), German MG3, British L7A2, French AAT NF1 (coaxial version of the AAT 52), Canadian C1 (caliber 7.
The interest in pharmacological intervention for patients with NF1 has grown in recent years.
Amerika Birlesik Devletleri Ulusal Saglik Enstitusu (NIH) tarafindan kabul edilen NF1 tani olcutleri soyledir.
Pirfenidone is an oral agent undergoing clinical investigation in NF1, where its antifibrotic properties are used to target the fibrotic component of plexiform neurofibromas.