UBA3

(redirected from NEDD8-activating enzyme E1C)

UBA3

A gene on chromosome 3p24.3-p13 that encodes the ubiquitous catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme, which activates NEDD8 and transfers it to the catalytic cysteine of UBE2M, where it downregulates steroid receptor activity. UBA3 is required for cell cycle progression.