NEDD8


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NEDD8

A gene on chromosome 14q12 that encodes a ubiquitin-like protein that plays an important role in cell cycle control and embryogenesis. Covalent attachment of NEDD8 to its substrates (neddylation) requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates E3 ubiquitin ligase activity, promoting polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
References in periodicals archive ?
The cell uses ubiquitin-like proteins such as NEDD8 to trigger special molecules that act as on switches for a variety of biochemical pathways, according to Brenda Schulman, Ph.
Schulman is the senior author of a report appearing in the March 20 issue of Nature on the structure and function of the E1 activating enzyme for NEDD8.
The complex series of reactions that control each function begins when a specific E1 activating enzyme combines an ubiquitin-like protein such as NEDD8 to an "escort" molecule.
The discovery of the structure of the E1 activating enzyme for NEDD8 helps explain the critical steps by which E1 links NEDD8 to its E2 escort.