NEDD8


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NEDD8

A gene on chromosome 14q12 that encodes a ubiquitin-like protein that plays an important role in cell cycle control and embryogenesis. Covalent attachment of NEDD8 to its substrates (neddylation) requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates E3 ubiquitin ligase activity, promoting polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
References in periodicals archive ?
DCUN1D2 and NEDD8 are present in non-myelinating Schwann cells.
Accumulation of DCUN1D2 and NEDD8 at the myelin paranodes is influenced by fiber diameter.
NEDD8 staining patterns showed similar results (Fig.
NEDD8 also appeared at the paranodal regions at P21, which was similar to DCUN1D2 (data not shown).
Similar changes were observed for NEDD8 localization in these fibers (Fig.
The present study demonstrated that two neddylation-related proteins, DCUN1D2 and NEDD8, are concentrated at the paranodal myelin region as well as in the myelinated and unmyelinated Schwann cell bodies.
Although NEDD8 was originally found in the embryonic mouse brain, (25) neddylation is now believed to have important roles in various cell functions in animals of all ages.
11)-(13) Since developmental analysis showed that DCUN1D2 and NEDD8 were simultaneously expressed at the paranode during the late stages of myelination, it is possible that mislocalization of these molecules is caused by loss of the paranodal junction.
45) Our developmental analyses showed that Schwann cell bodies in young animals were strongly immunostained by antibodies against DCUN1D2 and NEDD8.
2003) NEDD8 protein is involved in ubiquitinated inclusion bodies.
2005) Accumulation of NEDD8 in neuronal and glial inclusions of neurodegenerative disorders.