NCOA2

NCOA2

A gene on chromosome 8q13.3 that encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors, which are conditional transcription factors that play important roles in cell growth, development and homeostasis by controlling expression of specific genes.
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Assessing DNA copy number, messenger RNA expression, and focused exon resequencing in 218 prostate cancer tumors, the authors identified the role of nuclear receptor coactivator NCOA2 as a novel oncogene in 11% of PCa cases.
ACOXI, the human peroxisomal acylcoenzyme A oxidase, is hypothesized in the model to upregulate both RARI3 and NCOA2.
The only other linkage that did not appear to be supported by these data was the hypothesized linkage between NCOA2 and ZNF42.
Assessing DNA copy number, mRNA expression, and focused exon resequencing in 218 PCa tumors, the authors (74) identified the role of nuclear receptor coactivator NCOA2 as a novel oncogene in 11% of PCa cases.