NCK1

(redirected from NCK adaptor protein 1)

NCK1

A gene on chromosome 3q21 that encodes an adapter protein which associates with tyrosine-phosphorylated growth factor receptors (e.g., KDR and PDGFRB) or their substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. It plays a role in DNA damage response by activating downstream effectors, such as that of CHEK2, and in ELK1-dependent
transcriptional activation in response to activated Ras signalling.
References in periodicals archive ?
17 Other proteins include, POU class 5 homeobox 1 (OCT4), baculoviral IAP repeat containing 5 (BIRC5), cyclin D1 (CCND1), ATP binding cassette subfamily G member 2 (BCRP), SRY-box 2 (Sox2), Glutathione S-transferases (GST), NCK adaptor protein 1 (NCK1), human leukocyte antigen DQ (HLA-DQ), miR-106b, c-Myc, Ki67 and selective internal radiation therapy (SIRT).