orthostatic intolerance

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orthostatic intolerance

an abnormal response to standing upright that results from decreased blood pressure and inadequate blood flow to the brain, characterized by a variety of symptoms, including lightheadedness, palpitations, tremulousness, visual disturbances, and syncope. It occurs in both acute and chronic forms and is frequently seen as a transient condition in space travelers returning from microgravity. The cause is unknown but may be related to abnormalities in the autonomic regulation of cardiovascular function.

orthostatic intolerance

A condition (OMIM:604715) characterised by lightheadedness, fatigue, altered mentation, syncope and tachycardia upon assuming an upright position, and markedly elevated serum norepinephrine. 

Molecular pathology
Defects in SLC6A2, which encodes a member of the sodium:neurotransmitter symporter that regulates norepinephrine homeostasis, are a cause of orthostatic intolerance.

or·tho·stat·ic in·tol·er·ance

(ōr'thō-stat'ik in-tol'ĕr-ăns)
Decreased venous return in the upright position typically experienced by astronauts after returning to an environment subject to gravity.

orthostatic intolerance

Loss of consciousness, near fainting, or light-headedness occurring when a person stands up from a seated or resting position. It is caused by insufficient blood flow to the brain, typically brought on by inability to raise blood pressure during changes in posture.
References in periodicals archive ?
Dubai: Aiming to reduce premature mortality from Non-Communicable Diseases (NCD) by 25 per cent by 2025, medical professionals and experts from across the world convened at the first Global NCD Alliance Forum in Sharjah on Saturday, to try to bring to light the gravity of the issue as well as its social implications.
The event is a collaboration between FoCP and the NCD Alliance, which aims to unify global efforts to cut mortality caused by non-communicable diseases by 25% by 2025.
During her visit, she also attended an event entitled 'Strengthening the NCD civil society movement' taking place as part of the UN General Assembly week.
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The NCD official spokesman said that, according to the minutes of the previous session, participants considered a paper on explanations and definitions presented by representatives of the opposition national democratic societies dated 28th April 2013 regarding firm tenets, principles and values mentioned on their paper presented on 17 March 2013 in which they presented their remarks in this regard.
Yesterday was the deadline for the department to submit a reply to the affidavit filed by the NCD.
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will join Janice Lehrer-Stein who is returning to the Council, NCD Chairperson Jeff Rosen, and Council members Clyde Terry, Gary Blumenthal, Chester Finn, Sara Gelser, Ari Ne'eman, Kamilah Oni Martin-Proctor, Stephanie Orlando, Captain Jonathan F.