NALP3 inflammasome

NALP3 inflammasome

A well-characterised inflammasome (a multiprotein cytoplasmic complex which activates one or more caspases, leading to the processing and secretion of pro-inflammatory cytokines—e.g., IL-1 beta, IL-18 and IL-33) composed of NALP3, ASC, pro-caspase-1, and Cardinal. Assembly of inflammasomes depends on the NOD-like receptor family members, such as the NALP proteins.
References in periodicals archive ?
Expression and regulation of the NALP3 inflammasome complex in periodontal diseases.
Silica crystals and aluminum salts activate the nalp3 inflammasome through phagosomal destabilization.
Consequently, ROS overgeneration in the synovial membrane is associated with the inflammatory process mediated by NALP3 inflammasome, implicated in the development of KOA [27, 28].
Martinon F; Petrilli V; Mayor A; Tardivel A; Tschopp J Gout-associated uric acid crystals activate the NALP3 inflammasome.
The production of proinflammatory cytokines required two signalling pathways to be active, one initiated by the protein Tlr9 and one activated by a protein complex known as the Nalp3 inflammasome.
Based on data from preclinical studies and a clinical case series suggesting that blockade of the NALP3 inflammasome IL-1 pathway may be an effective treatment strategy for gout, as well as the promising results of a phase III trial of the drug in patients with cryopyrin-associated periodic syndrome (CAPS) arising from NALP3 mutations, Dr.
sup][33]showed that chrysophanic acid improved the permeability of the blood-brain barrier by inhibiting NALP3 inflammasome activation in rats with injury-induced cerebral ischemia reperfusion by transient middle cerebral artery occlusion.
Among antioxidant drugs, resveratrol protects the heart during I/R injury by inhibition of NALP3 inflammasome and ROS production [67] (Figure 1).
Malarial hemozoin is a Nalp3 inflammasome activating danger signal.
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration.