NAB2

NAB2

A gene on chromosome 12q13.3 that encodes NGFI-A-binding protein 2, which downregulates transcription by zinc finger transcription factors EGR1 and EGR2.
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Notable upregulated genes were involved in neuron differentiation ( BTG2, NTNG2, DLL1, HES1, NR4A2, STAT3, and VEGF-A ), myeloid cell and osteoclast differentiation ( KLF10, TOB2, and ZFP36 ), cellular and macromolecular biosynthetic process ( KLF13, MKL1, HES1, MYOG, NR4A1, NR4A2, STAT3, and MAF ), and skeletal system development (JUND, KLF10, NAB2, MYOG, and TIPARP ).
NAB2 is a transcriptional corepressor, a regulator of the early growth response 1 (EGR1) transcription factor.
Because STAT6 and NAB2 are located close together on the long arm of chromosome 12, FISH to demonstrate rearrangement of the genes is technically challenging and not diagnostically useful.