FOLH1

(redirected from NAALADase I)

FOLH1

A gene on chromosome 11p11.2 that encodes folate hydrolase 1, which has both folate hydrolase (FH) and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. It acts as an FH in the intestine and is required for the uptake of folate; in the brain, it modulates excitatory neurotransmission by hydrolysing the neuropeptide N-aceylaspartylglutamate (NAAG), releasing glutamate. It is highly expressed in the prostate.
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NAALADase is believed to play a role in modulating the release of glutamate, one of the most common chemical messengers between nerves.
NAALADase is the same protein as prostate specific membrane antigen (PSMA), a protein found on the surface of prostate cancer cells.
Three other studies showed that despite these potent effects, NAALADase inhibitors do not seem to alter normal brain activity in animals, and that NAALADase is only found in human brain, prostate, liver, small intestine, and kidney.