EPI-506 was designed to block a novel target on the androgen receptor, the N-terminal
HA consists of the receptor-binding HA1 and the fusion-mediating HA2, which has two membrane-interacting elements: the N-terminal
fusion peptide and a C-terminal transmembrane anchor.
Messersmith, Hu, and Su developed biocompatible macromonomer hydrogels using a thioester that readily reacts with an N-terminal
thiol (cysteine) through transesterification and rearrangement to form an amide bond through a five-member ring intermediate.
This new service includes C-terminal labeling, N-terminal
labeling, and Labeling at glycosylation sites.
These insights led the authors to propose a new "lock and trigger" model for spider silk formation, in which gradual pairing up of the N-terminal
domains locks spidroins into a network of many protein molecules, while the changes of structure in the C-terminal domains could trigger the rapid polymerization of spidroins into fibers.
The authors also found that while N-terminal
domain tended to pair up with other molecules at the beginning of the duct and became increasingly stable as the acidity increased along the duct, the other end the C-terminal domain destabilized as the acidity increased, and gradually unfolded until it formed the structure characteristic of silk at the acidic pH of 5.
The 15 N-terminal
amino acid sequences had some resemblance to those other of protease inhibitors and inhibitor precursors from leguminous plants.
A third locally developed RIA that we named the "commercial assay" recognized the inner portion of the N-terminal
arm of BNP and used a diluted commercial antiserum to BNP(1-32) (T-4021, Bachem).
Siva-1 consists of several distinct domains: an N-terminal
region, a putative amphipathic helical (SAH) region, a death domain homology region (DDHR), and a C-terminal cysteine-rich region that includes a B-BOX domain and a zinc-finger-like domain (2,3).
Serum calcium, phosphorus, magnesium, 25-OH Vitamin D, parathormone (PTH), alkaline phosphatase (ALP), and biochemical markers of bone formation (Osteocalcin, Bone-ALP) and resorption ( N-terminal
collagen type 1 and C terminal collagen type 1) were determined.
The cardiac biomarker N-terminal
proBNP (NT-proBNP) and echocardiographic changes were monitored and mortalities were registered.
LOS ANGELES--In terms of preserving exercise capacity and lowering elevated N-terminal
pro-B-type natriuretic peptide levels, calcium channel blockers outperformed beta-blockers for rate control in patients with permanent atrial fibrillation.