N-telopeptide

N-telopeptide

,

NTx

A biomarker of osteoclast-induced bone resorption. Detection of NTx is used, for example, to detect bone breakdown in patients with osteopenia or osteolysis.

Also known as cross-linked N-telopeptide of type 1 collagen.

References in periodicals archive ?
Markers of bone remodeling serum C-telopeptide (CTx) and urinary N-telopeptide (NTx)
As expected, urinary collagen type I cross-linked N-telopeptide, a biomarker of bone resorption, increased with placebo, compared with a significant 47% decrease with odanacatib.
The interim results showed that Alpharadin helped reduce the levels of bone alkaline phosphatase (bALP) and urine N-telopeptide (uNTX), two key parameters of bone involvement in breast cancer.
Complete blood count (CBC), the metabolic panel, blood lipid profile, serum osteo calcium and urine N-telopeptide crosslinks, thyroid profile, were all performed by Lab Corp.
8 percent in alkaline phosphatase, a marker of bone formation, and a decrease of 54 percent in urine N-telopeptide, a marker of bone resorption.
At the same time, urinary N-telopeptide level, a marker of bone resorption, decreased by 20% at 3 months, 33% at 12 months, and 54% at 24 months.
Additionally, compared with placebo, treatment with nitroglycerin was significantly associated with an increase in bone-specific alkaline phosphatase, a marker of bone formation; and a decrease in urine N-telopeptide, a marker of bone resorption.
Calcium will be present in urine and bone markers of reabsorption, such as N-telopeptide pyridinoline, and deoxypyridinoline may be present.
Osteocalcin and N-telopeptide significantly decreased at all BZA-estrogen dosages, compared with placebo, and at most BZA-estrogen dosages, compared with raloxifene.
Bone alkaline phosphatase activity and serum N-telopeptide concentration increased appreciably over the same period of time.