The abilities of 5,6-benzoflavone (5,6-BF, a synthetic flavonoid), indole-3-carbinol (I3C, a plant derived product) or diindolylmethane (DIM, a condensation product of I3C) to alter the induction of mammary cancers induced by the carcinogens 7,12-dimethylbenzanthracene (DMBA) or N-methyl-N-nitrosourea
(MNU) were evaluated.
Compounds being tested include methylmethoxymethanol, which comes from the naturally occurring toxin cycasin (from a plant in the cycad family), as well as N-methyl-N-nitrosourea
and methyl methane sulfonate, both of which are synthetic compounds found in grilled foods and smoke.
Rats were given the potent carcinogen N-methyl-N-nitrosourea
to induce multiple breast tumors.
The HCSE inhibited the genotoxicities of furylfuramide, N-methyl-N-nitrosourea
, methyl methanesulfonate, mitomycin C, 2-aminoanthracene and aflatoxin B1 at a concentration of 1 mg/ml or more.
Prostate carcinogenesis in N-methyl-N-nitrosourea
(NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.