N-acetylserotonin


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N-acetylserotonin

A natural chemical intermediate in the production of melatonin from serotonin, and is produced by aralkylamine N-acetyltransferase (AANAT) and is converted to melatonin by acetylserotonin O-methyltransferase (ASMT). It acts as neurotransmitter at melatonin receptors MT1, MT2 and MT3. NAS’s distribution suggests that it may not be limited in its role as a melatonin precursor.
References in periodicals archive ?
Then, 5-HT is transformed to N-acetylserotonin by arylalkylamine-N-acetyltransferase (AANAT).
TNF[alpha] inhibits AANAT mRNA expression as well as the synthesis of the melatonin precursor N-acetylserotonin [14].
GABA enhanced the catabolism of serotonin to N-acetylserotonin, a precursor to melatonin in rats.
The Influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophan and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar Rat.
Now Scientists at Emory University School of Medicine have shown that N-acetylserotonin can stimulate the same circuits in the brain activated by the growth factor BDNF (brain-derived neurotrophic factor).
The Effect of Methylene Blue and Related Redox Dyes on MAO Activity, Rat Pineal N-Acetylserotonin, Melatonin, and Related Indoles Content, and on the Righting Reflex in Melatonin-primed Frogs: G.
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