GALNS

(redirected from N-acetylgalactosamine-6-sulfate sulfatase)

GALNS

A gene on chromosome 16q24.3 that encodes N-acetylgalactosamine-6-sulfatase, a lysosomal exohydrolase required for the degradation of glycosaminoglycans, keratan sulfate and chondroitin 6-sulfate.

Molecular pathology
Defects of GALNS cause Morquio A syndrome, a lysosomal storage disease.
References in periodicals archive ?
Morquio A syndrome is a rare, autosomal recessive lysosomal storage disease caused by a deficiency in N-acetylgalactosamine-6-sulfate sulfatase (GALNS).
N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.
Morquio syndrome type A, or mucopolysaccharidosis IVA (MPS-IVA), [4] is an autosomal recessive disorder that causes a deficiency of lysosomal N-acetylgalactosamine-6-sulfate sulfatase (GALNS) (EC 3.
N-Acetylgalactosamine-6-sulfate sulfatase in human placenta: purification and characteristics.
A Novel Common Missense Mutation G301C in the N-Acetylgalactosamine-6-sulfate Sulfatase Gene in Mucopolysaccharidosis IVA.
Characterization and pharmacokinetic study of recombinant human N-acetylgalactosamine-6-sulfate sulfatase.

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