GALNS

(redirected from N-acetylgalactosamine-6-sulfatase)

GALNS

A gene on chromosome 16q24.3 that encodes N-acetylgalactosamine-6-sulfatase, a lysosomal exohydrolase required for the degradation of glycosaminoglycans, keratan sulfate and chondroitin 6-sulfate.

Molecular pathology
Defects of GALNS cause Morquio A syndrome, a lysosomal storage disease.
References in periodicals archive ?
Mucopolysaccharidosis IVA (MPS IVA, also known as Morquio A Syndrome) is a disease characterized by deficient activity of N-acetylgalactosamine-6-sulfatase (GALNS) causing excessive lysosomal storage of keratan sulfate (KS).

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