N-acetylaspartate


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N-ac·e·tyl·as·par·tate

(as'ĕ-til-as-par'tāt),
An acetylated derivative of aspartate found in the brain. Used as a marker in brain nuclear magnetic resonance and in neuroimaging.
References in periodicals archive ?
MRI spectroscopy revealed reduced N-acetylaspartate concentrations in diabetes patients with multiple episodes of DKA, compared with healthy controls, but no significant differences were seen between diabetes patients with and without DKA.
MR spectroscopy is a non-invasive diagnostic method that can be used for metabolic characterization of brain tumors to better predict the grade of the glioma; based on the analysis of the choline (Cho), N-acetylaspartate (NAA) and creatine (Crn) peaks.
Our MRS data showed reduced N-acetylaspartate (NAA) (pless than 0.
1]H-MRS include N-acetylaspartate (NAA; a marker of neuronal integrity), choline-containing compounds (Cho; a marker of membrane turnover and glial proliferation), and creatine with phosphocreatine (Cre; a marker of tissue energetic metabolism, usually considered an internal control).
The spectrally selective pulse is based on a Shinnar-Le Roux (SLR) algorithm [2, 5] and was modified to target four metabolites: Lactate (Lac), N-acetylaspartate (NAA), Creatine (Cre) and Choline (Cho).
A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease.
3) Raised choline and creatine levels with low N-acetylaspartate have been observed in the acute phase with levels of these neurochemicals returning to normal post treatment.
219) investigating whether in vivo brain levels of [gamma]-aminobutyric acid (GABA), N-acetylaspartate (NAA), and other brain metabolites in smelter workers might be altered as a consequence of Mn exposure.
Blood tests indicated absolute concentrations of N-acetylaspartate (NAA), choline, creatine, and myoinositol.
It implies that certain chemicals embedded within the neurons, such as myo-inositol and N-acetylaspartate, might be abnormal in people who present psychiatric symptoms.
These compounds are most notably N-acetylaspartate (NAA), choline (Cho), creatine and phosphocreatine (Cr), and myo-inositol (m-I), as well as lipid and lactate.
A subset of 26 out of 31 subjects underwent one or two proton magnetic resonance spectroscopy (MRS) studies to detect both steady-state levels and ratios of three brain metabolites: N-acetylaspartate (NAA), choline (Cho), and creatine (Cr).
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