N-acetylaspartate


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N-ac·e·tyl·as·par·tate

(as'ĕ-til-as-par'tāt),
An acetylated derivative of aspartate found in the brain. Used as a marker in brain nuclear magnetic resonance and in neuroimaging.
References in periodicals archive ?
The spectrally selective pulse is based on a Shinnar-Le Roux (SLR) algorithm [2, 5] and was modified to target four metabolites: Lactate (Lac), N-acetylaspartate (NAA), Creatine (Cre) and Choline (Cho).
3) Raised choline and creatine levels with low N-acetylaspartate have been observed in the acute phase with levels of these neurochemicals returning to normal post treatment.
219) investigating whether in vivo brain levels of [gamma]-aminobutyric acid (GABA), N-acetylaspartate (NAA), and other brain metabolites in smelter workers might be altered as a consequence of Mn exposure.
Blood tests indicated absolute concentrations of N-acetylaspartate (NAA), choline, creatine, and myoinositol.
These compounds are most notably N-acetylaspartate (NAA), choline (Cho), creatine and phosphocreatine (Cr), and myo-inositol (m-I), as well as lipid and lactate.
Previous research has concluded that heavy drinking is associated with depleted cortical gray matter volume and diminished levels of N-acetylaspartate (a marker of neuronal viability) in the lower frontal white matter and gray matter, said Dr.
2003 alcoholics had reductions in spectroscopy (MRS) to frontal lobe white-matter measure concentrations N-acetylaspartate (a marker of N-acetylaspartate.
The MR spectroscopy study found that veterans with Syndrome 2 had 18% less N-acetylaspartate (NAA) in the right basal ganglia and 26% less NAA in the brain stem, compared with healthy veterans of the same age, sex, and educational level.
In addition, N-acetylaspartate and N-acetyl-aspartyl-glutamate, novel metabolites in the ovary, were identified, although the role of these molecules in ovarian physiology has not yet been determined.
MR spectroscopy did not reveal raised N-acetylaspartate (NAA) or myoinositol peak.
METHODS: We performed MRS on 15 men selected from the lowest quintile of patella bone lead within the Department of Veterans Affairs' Normative Aging Study (NAS) and 16 from the highest to assess in the hippocampal levels of the metabolites N-acetylaspartate, myoinositol, and choline, each expressed as a ratio with creatine.
A subset of 26 out of 31 subjects underwent one or two proton magnetic resonance spectroscopy (MRS) studies to detect both steady-state levels and ratios of three brain metabolites: N-acetylaspartate (NAA), choline (Cho), and creatine (Cr).
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