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An acetylated derivative of aspartate found in the brain. Used as a marker in brain nuclear magnetic resonance and in neuroimaging.
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10,11] After measuring the neurometabolism on white matters of the frontal lobe in OCD teenage patients via MR scanner, Weber and colleagues [12] reported that the decline of choline and N-Acetyl Aspartate (NAA) was found to be significant in these white matters, and the relationship between the decrease of substances and clinical symptoms of OCD was significant.
Decreased N-acetyl aspartate in the absence of atrophy in the hippocampus of posttraumatic stress disorder.
Major Finding: Ratios of N-acetyl aspartate to choline in the frontal cortex of children with obstructive sleep apnea normalized after treatment, correlating to improvements in verbal memory and attention.
One-way ANOVA was used to compare the P values among different regions tNAA; N-acetyl aspartate + NAAG; dipeptide N-acetylaspartylglutamate, Cr; Creatine, PCr; phosphocreatine Cho; Choline containing compound, Glx; glutamate (Glu) and glutamine (Gln); myo-inositol (mI) Table IV.
A decrease in N-acetyl aspartate, a marker or neuronal function, also may play a role.
From her post at UC, Delbello and her team examine neuro-chemical abnormalities of affected children and adolescents and have found that certain neuro-chemicals, such as myo-inositol, which is associated with second-messenger cellular signaling pathways, and N-acetyl aspartate, which is a potential marker of neuronal function and structure, are abnormal in patients with BD.
Montreal Neurological Institute, Quebec, Canada) investigated the connection between fatigue and brain levels of n-acetyl aspartate (NAA), a chemical marker that indicates whether nerve fibers are intact and functioning properly.
The most remote study from December 2004 shows elevated choline (Cho) peaks relative to creatine (Cr) and N-acetyl aspartate (NAA) (Figure 2).
Three major metabolites are found in normal brain spectrum: N-Acetyl Aspartate (NAA), Creatine (Cr), and Choline (Cho).
At MR spectroscopy, the lesions will show decreased N-acetyl aspartate (NAA) and elevated choline.
An earlier study by other investigators looked at the levels of N-acetyl aspartate, a marker of neuronal viability, before and after 4 weeks of lithium therapy both in 12 untreated bipolar patients and 9 healthy controls.
Murphy's group assessed n-acetyl aspartate, a marker for neuron density, and choline, a marker for myelin sheath degeneration in the hippocampus and the temporal and parietal lobes; these are the parts of the brain that suffer the greatest damage in patients with AD.
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