This work has also led to the surprising observation that the N-Myc
protein, which drives neuroendocrine tumorigenesis, is stabilized by association with the Aurora-A kinase and that clinically available Aurora-A inhibitors can dissociate the complex and destabilize N-Myc
Alt proved the generality of his initial discoveries when he showed that the gene n-myc
is commonly amplified in the childhood cancer neuroblastoma.
And although the cancer has not spread past the tumour site, the cells show a genetic abnormality called N-MYC
The researchers identified two proteins, each linked to different aspects of sleep: phosphorylated dynamin 1 levels were related to how long it took to fall asleep, while phosphorylated N-myc
gene 2 protein levels tracked the amount of sleep deprivation and corresponded to the well-known brain wave measure of sleep need.
One 3-month old patient underwent partial cystectomy with negative surgical margins, but had poor-risk prognostic indicators, such as unfavourable Shimeda classification, n-myc
amplification and 1p chromosome deletion, with lymph node extension.
The researchers identified two proteins that affected these responses, each linked to different aspects of sleep: phosphorylated dynamin 1 levels were linked to how long it took to fall asleep, while phosphorylated N-myc
downstream regulated gene 2 protein levels tracked the amount of sleep deprivation and corresponded to the well-known brain-wave measure of sleep need, they report.
4] Human genes: TMPRSS2, transmembrane protease, serine 2; ERG, v-ets erythroblastosis virus E26 oncogene homolog (avian); SLC45A3, solute carrier family 45, member 3; ETV1, ets variant 1; NDRG1, N-myc
downstream regulated 1.
The Myc family of oncoproteins (c-Myc, N-Myc
, and L-Myc) regulate critical pathways that contribute to tumors; c-Myc expression, which is activated in human Burkitt lymphoma, is sufficient to induce the growth of several tumor types in animal models.
The contributors share recent findings on cognitive disruption in Angelman syndrome, cultural differences in infantile amnesia, drug-induced neuronal plasticity occurring at excitatory synapses in the brain, and the N-Myc
downstream-regulated gene family.
It is a downstream target gene of N-myc
and comprises one of four NDRG family members.
THE ONCOGENE N-MYC
AND ITS REGULATORY ROLE IN THE TRANSCRIPTION OF N-ACETYLGLUCOSAMINYLTRANSFERASE VB IN NEUROBLASTOMAS.
Recently, the Australian team inserted a cell-proliferation gene called N-myc
alongside a gene that regulates keratin synthesis in mice.