MYCN

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MYCN

A gene on chromosome 2p24.3 that encodes a DNA-binding transcription factor.
 
Molecular pathology
MYCN mutation causes Feingold syndrome; MYCN is amplified in various tumours, especially in neuroblastomas.
References in periodicals archive ?
c-Myc belongs to a family of related genes, N-Myc and L-Myc.
During treatment, the family were dealt another blow - Cannon had a gene called N-myc amplified, which means sufferers are far more likely to relapse.
Berberine attenuated cancer sternness markers CD133, [beta]-catenin, n-myc, sox2, notch2 and nestin.
Hereditary neuroblastoma predisposition gene is in chromosome 16p12-13, Amplification of the N-MYC Oncogene seen in roughly 20% and Deletion of the short arm of chromosome 1.
Using RT-qPCR, we evaluated the relative expression level of 17 genes involved in polyamine metabolism and 4 genes mediating metabolic reprogramming, and the regulation of inflammatory response and cell proliferation: c-Myc (MYC), n-Myc (MYCN), Max, and C/EBP[beta] gene encoding CCAAT/enhancer binding protein (CEBPB).
N-myc downstream-regulated gene 2 (NDRG2, Protein Accession No: Q9UN36) is a 41 kDa cytoplasmic protein of NDRG family, which encodes by human NDRG2 gene (GenBank Accession No.
This work has also led to the surprising observation that the N-Myc protein, which drives neuroendocrine tumorigenesis, is stabilized by association with the Aurora-A kinase and that clinically available Aurora-A inhibitors can dissociate the complex and destabilize N-Myc.
Nuclear Regulatory Proteins: Transcriptional activators C-MYC, N-MYC, L-MYC
And although the cancer has not spread past the tumour site, the cells show a genetic abnormality called N-MYC Amplification.
1) c-MYC belongs to a family of transcription factors, which also includes N-MYC, L-MYC, and S-MYC.
The researchers identified two proteins, each linked to different aspects of sleep: phosphorylated dynamin 1 levels were related to how long it took to fall asleep, while phosphorylated N-myc gene 2 protein levels tracked the amount of sleep deprivation and corresponded to the well-known brain wave measure of sleep need.
One 3-month old patient underwent partial cystectomy with negative surgical margins, but had poor-risk prognostic indicators, such as unfavourable Shimeda classification, n-myc amplification and 1p chromosome deletion, with lymph node extension.