nonoxynol-9

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nonoxynol-9

(nŏn-ŏk′sə-nôl′nīn′, -nŏl′-, -nōl′-)
n.
A spermicide widely used in contraceptive creams, foams, and lubricants.

nonoxynol-9

A SURFACTANT spermicidal drug intended for use in conjunction with barrier contraceptives. It is available as a foam, pessary, gel, or cream. Brand names are Delfen, Double Check, Ortho-Forms, Duragel, Gynol II and Ortho-Creme.
References in periodicals archive ?
Thus there was a significant decrease in sperm viability in the Ap and N-9 treated groups when compared to the control group (Fig.
The release of inorganic phosphate was maximum in the control and was significantly reduced in Ap and N-9 treated groups.
Christine Mauck commented that the findings are consistent with earlier observations that the differences in lesions between placebo and N-9 are seen only in frequent users.
Therefore, N-9 should not be used as a microbicide or lubricant during anal sex.
Since adverse effects due to the addition of N-9 to condoms cannot be excluded, such condoms should no longer be promoted.
The WHO and CDC recommendations are based, in part, on an analysis of 10 randomized clinical trials of the effectiveness of N-9 against HIV or other STIs, involving almost 5,000 women, that included trials conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and FHI.
Whether N-9 adds contraceptive protection to barrier methods other than condoms is still unknown, although spermicide use with the diaphragm is recommended.
Now that there is a clear, official consensus that N-9 is harmful, especially for rectal use, it is likely to start disappearing from condoms and lubes.
Organizers of the Call emphasize that removing N-9 from condoms and lubricants would benefit women as well as gay men.
Recent research has shown that even small amounts of N-9 can cause sloughing of the cell lining of the rectum, potentially increasing one's risk of contracting HIV," said Dr.
After presentation of the preliminary results from the study in July 2000, the World Health Organization (WHO) was approached to provide an assessment of the scientific information regarding the safety and effectiveness of N-9 when used for family planning purposes.
This report summarises the evidence presented to the meeting on the safety of N-9 and its effectiveness for protection against pregnancy, sexually transmitted infections (STIs) and HIV.