MX1

(redirected from Myxovirus resistance protein 1)

MX1

A gene on chromosome 21q22.3 that encodes a dynamin-like GTPase which acts as a cell-autonomous host restriction factor against many viral pathogens, including influenza viruses, rhabdovirus VSV, bunyavirus LACV, Thogoto virus, measles virus, Hanta virus, Coxsackie virus CVB, Rift Valley fever virus, HBV, and Crimean-Congo haemorrhagic fever virus.
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ABSTRACT: The mouse myxovirus resistance protein 1 (Mx1) is known to be sufficient to confer resistance to influenza viruses, and the gene encoding Mx1 is, therefore, an interesting candidate gene for disease resistance in farm animals.