This phenomenon might be followed by an increase in the contraction of myoepithelial
Early microarray studies defined a molecular subtype known as basal (from similarity to the transcriptome observed in basal myoepithelial
cells of the breast) (15, 16), which has a strong overlap with TNBC status.
However, the retention of a myoepithelial
layer is indicative of its in situ nature.
Even more surprising was that sweat gland myoepithelial
cells produced epidermis when engrafted to the back skin of the mice.
Hicks: "In my laboratory, I use ADH-5 if I am worried about microinvasion since it clarifies whether the myoepithelial
layer is intact, resolving potential misdiagnosis due to lobular cancerization and sclerosing adenosis, and helps to visualize tumor cells masked by inflammatory processes.
Key words: bitch, mammary gland, myoepithelial
cells, carcinomas in mixed and complex tumours.
Inoculation of cadmium-treated cells into mice produced invasive, metastatic anaplastic carcinoma with myoepithelial
Microstructure of the vesicle is made up of a double cell layer consisting of an outer layer of myoepithelial
cells that function as a contractile component and an inner layer of secretory cells that is continuous with the vesicle contents (Hostetler & Cannon 1974; Cannon & Hostetler 1976).
Oxytocin release from the pituitary as well as the placenta increases markedly in the early phases of labor, as does production of oxytocin receptor proteins by the myometrium and the myoepithelial
cells of the breast.
Histology of the excised specimen identified proliferating ductules within a myxoid stroma, with spindle- to oval-shaped myoepithelial
cells and no mitotic figures (figure 2).
In fact, the adipocytes and glandular cells in normal mouse breast tissue expressed CPN weakly or not at all, whereas the myoepithelial
cells exhibited an increased concentration of CPN.
Cytokeratins 5 and 6 are related proteins that can be detected in normal cells, including breast myoepithelial
cells, prostate basal cells, and the basal layer of the epidermis and salivary glands.