myocardin


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myocardin

(mĪ-ō-kahr'din),
A specific protein that is expressed in cardiac and smooth muscles cells. It has a role as a transcription factor and coactivates cardiac muscle promoters by associating with a serum response factor SRF protein; implicated in vascular smooth muscle cell differentiation.
References in periodicals archive ?
SRF binds to certain snippets of DNA called CArG boxes and serves as an anchor, while myocardin piggybacks along and turns on the genes to which SRF sticks.
They found that when SRF and myocardin work together, they turn on a protein known as SREBP2, which inhibits a molecule known as LRP-1, which helps the body remove amyloid beta.
Olson and fellow researchers focused on a molecule called Foxo4, to see whether it might control myocardin; they found that it turns off myocardin, thus allowing smooth muscle cells to stop contracting and grow.
Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment.