myocardin


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myocardin

(mĪ-ō-kahr'din),
A specific protein that is expressed in cardiac and smooth muscles cells. It has a role as a transcription factor and coactivates cardiac muscle promoters by associating with a serum response factor SRF protein; implicated in vascular smooth muscle cell differentiation.
References in periodicals archive ?
SRF binds to certain snippets of DNA called CArG boxes and serves as an anchor, while myocardin piggybacks along and turns on the genes to which SRF sticks.
Olson and fellow researchers focused on a molecule called Foxo4, to see whether it might control myocardin; they found that it turns off myocardin, thus allowing smooth muscle cells to stop contracting and grow.
The team named the newly identified protein myocardin, after the word for heart muscle.