| Dictionary, Encyclopedia and Thesaurus - The Free Dictionary 3,901,502,789 visitors served. |
Dictionary/ thesaurus | Medical dictionary | Legal dictionary | Financial dictionary | Acronyms | Idioms | Encyclopedia | Wikipedia encyclopedia | ? |
metolazone |
Also found in: Wikipedia | 0.01 sec. |
|
|
metolazone /me·to·la·zone/ (mĕ-to´lah-zōn) a sulfonamide derivative with actions similar to the thiazide diuretics; used in the treatment of hypertension and edema.
metolazone [mətō′ləzōn] a diuretic. indications It is prescribed for the treatment of edema and mild to moderate high blood pressure. contraindications Anuria or known hypersensitivity to this drug, to thiazides, or to sulfonamides prohibits its use. adverse effects Among the more serious adverse effects are hypokalemia, hyperglycemia, hyperuricemia, and allergic reactions. metolazone (metō´l
n brand names: Diulo, Mykrox, Zaroxolyn; drug class: diuretic with thiazidelike effects; action: acts on distal tubule by increasing excretion of water, sodium, chloride, and potassium; uses: edema, hypertension, CHF. metolazone a diuretic and saluretic.
metolazone Zaroxolyn Pharmacologic class: Thiazide-like diuretic Therapeutic class: Diuretic, antihypertensive Pregnancy risk category B ActionInhibits electrolyte reabsorption from ascending loop of Henle and decreases reabsorption of sodium and potassium in distal renal tubules, increasing plasma osmotic pressure and promoting diuresis AvailabilityTablets: 2.5 mg, 5 mg, 10 mg ⊘Indications and dosages ➣ Hypertension Adult: 2.5 to 5 mg P.O. daily. ➣ Edema caused by heart failure or renal disease Adults: 5 to 20 mg P.O. daily Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration• Give in morning to avoid frequent nighttime urination.
Adverse reactionsCNS: drowsiness, lethargy, vertigo, paresthesia, weakness, headache, fatigue CV: chest pain, hypotension, palpitations, venous thrombosis, arrhythmias GI: nausea, vomiting, bloating, cramping, anorexia, pancreatitis GU: polyuria, nocturia, erectile dysfunction, decreased libido Hematologic: aplastic anemia, leukopenia, agranulocytosis Hepatic: hepatitis Metabolic: dehydration, hypercalcemia, hypomagnesemia, hyponatremia, hypophosphatemia, hypovolemia, hyperglycemia, hyperuricemia, hypokalemia, hypochloremic alkalosis Musculoskeletal: muscle cramps Skin: photosensitivity, rashes Other: chills InteractionsDrug-drug. Amphotericin B, corticosteroids, mezlocillin, piperacillin, ticarcillin: additive hypokalemia Antigout drugs: increased uric acid level Antihypertensives, nitrates: additive hypotension Digoxin: increased risk of digoxin toxicity Lithium: decreased lithium excretion, increased risk of lithium toxicity Drug-diagnostic tests. Bilirubin, calcium, cholesterol, creatinine, low-density lipoproteins, triglycerides, uric acid: increased levels Blood glucose, urine glucose: increased levels in diabetic patients Magnesium, potassium, protein-bound iodine, sodium, urinary calcium: decreased levels Drug-food. Any food: increased metolazone absorption Drug-herbs. Aloe, cascara sagrada, senna: increased risk of hypokalemia Drug-behaviors. Sun exposure: increased risk of photosensitivity Patient monitoring• Monitor baseline and periodic electrolyte, blood urea nitrogen, glucose, and uric acid levels. Patient teaching• Advise patient to take in morning to avoid frequent nighttime urination. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
|
| Mentioned in | ? | References in periodicals archive | ? | Medical browser | ? | Full browser | ? | |||
|---|---|---|---|---|---|---|---|---|---|---|
The inspection also provided a GMP update under the Drug Pilot Program with coverage of Mykrox tablets and Zaroxolyn (metalazone 2. The inspection also provided a GMP update under the Drug Pilot Program with coverage of Mykrox tablets and Zaroxolyn (metalazone 2. |
Mykrox |
Mykênê Mykênê Mykênes Mykênes Mykhlik, Vasilii Ilich Mykinac Mykinac Mykinac Mykiss Mykiss Myklestad method MYKO myko- myko- Mykola Bazhan Mykola Gogol Mykola Hohol Mykola Kibalchich Mykola Leontovych Mykolaitis-Putinas, Vincas Mykolaiv Mykolaiv Mykolaiv Oblast Mykolas Sleževicius Mykolas Slezevicius Mykolas Songaila Mykolayiv Mykolayiv Mykonos Mykonos Mykrox MYKSMYKSH MYL MYLA MYLA Mylabridae Mylabris Mylabris phalerata Mylabris sidae Mylae Mylae Mylanchi Mylanchi Mylanta Mylanta Mylanta Mylanta AR Mylanta AR Mylanta Children's Mylanta Children's Mylanta Children's Mylanta Gas Mylanta Gas Relief Mylar Mylar City MYLC Myle Myle Myle Myle | ||||||||
| Medical Dictionary |
| Free Tools: |
For surfers:
Free toolbar & extensions |
Word of the Day |
Help
For webmasters: Free content | Linking | Lookup box | Double-click lookup |
|---|