CCL23

(redirected from Myeloid progenitor inhibitory factor 1)

CCL23

A gene on chromosome 17q12 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL23 binds CCR1; it is chemotactic for resting T lymphocytes and monocytes, has some effect on neutrophils and no effect on activated T lymphocytes. CCL23 is a strong suppressor of colony formation by multipotential haematopoietic stem cells.
References in periodicals archive ?
MPIF-1, or Myeloid Progenitor Inhibitory Factor 1, is a completely new chemoprotectant which, based on preclinical studies, shields hematopoietic progenitor cells in the bone marrow from the effects of a number of chemotherapeutic agents used to treat all major cancers.