Disease Pathology Inheritance Genes/chromosomal name (a) mode loci associated with disease, n CMT1 Abnormal myelin AD (b) 9 CMT2 Axonopathy AD 19 CMT4 Either myelinopathy
AR 10 or axonopathy CMTX Axonopathy with XLD 2 secondary myelin changes Disease Proportion name (a) of all CMT, % CMT1 40-50 CMT2 10-15 CMT4 Rare CMTX 10-15 (a) Intermediate dominant (dominant inheritance with NCV between demylinating and axonopathic) and other rare forms are not included.
Sadick N, Strenberg PE: Vacuolar myelinopathy
of the brain and lamellar ichthyosis.
Additionally, hydrilla has been implicated in the spread of an emerging avian disease known as avian vacuolar myelinopathy that affects herbivorous waterbirds and their predators (11), (12), (13).
Birrenkott AH, Wilde SB, Hains JJ, Fischer JR, Murphy TM, Hope CP, Parnell PG, and Bowerman WM: Establishing a food-chain link between aquatic plant material and avian vacuolar myelinopathy in mallards (Anas platyrhynchos).
Lewis-Weis LA, Gerhold RW, and Fischer JR: Attempts to reproduce vacuolar myelinopathy in domestic swine and chickens.
Autopsy showed spongy myelinopathy
, intramyelinic edema, and foamy macrophages, with minimal brain stem and cerebellum involvement.
Researchers at the University of Georgia are working to determine the cause of Avian Vacuolar Myelinopathy
which has killed eagles and other birds in four states, which is currently unknown.
However, the discovery of the disease in other waterfowl species in 1999 prompted a change; the disease is now called Avian Vacuolar Myelinopathy
, or AVM.