central pontine myelinolysis (redirected from Myelinolysis, central pontine)

central pontine myelinolysis

Neuropathology A condition characterized by softening of the base of the brain at the pons with damage to the myelin sheath, related to aggressive correction of hyponatremia; first identified in alcoholics–Wernicke-Korsakoff syndrome, CPM also occurs in AIDS, infection, lymphoproliferative disorders–eg, AML, malnutrition, and venous obstruction Clinical Weakness, double vision, muscle spasms, speech defects, delirium, sleep disorders, hallucinations, tremors and uncontrolled eye movements Imaging Defects are seen by MRI Prevention Slow correction of electrolytic imbalance