Mice doubly deficient in the genes for P0 and myelin basic protein
show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin.
This calming effect may extend to immune cells targeting central nervous system proteins besides myelin basic protein
Expression of a novel transcript of the myelin basic protein
5,11] EAE is an experimental model of MS that is induced by the injection of myelin basic protein
The researchers infected the mice with a virus that has itself been engineered to produce myelin basic protein
Both are different from antibody that binds to myelin basic protein
, and so on.
Protein sequence databases were generated for myelin basic protein
, proteolipid protein/DM-20, protein zero, 2', 3'-cyclic nucleotide phosphodiesterase (CNP) mal, and PMP22.
When the scientists exposed rats to the gas, an abundant brain protein called myelin basic protein
underwent chemical changes.
The proteins S100B, neuron-specific enolase (NSE)  myelin basic protein
, and the recently introduced glial fibrillary acidic protein are currently being evaluated as protein markers in cerebrospinal fluid and/or blood for detection of brain injury in neurologic patients (1-3) and patients with cerebrovascular accidents (4), traumatic brain injury (5), stroke (6), global cerebral ischemia attributable to cardiac arrest or cardiopulmonary bypass surgery (7, 8), tumor cerebri (9), or dementia (10), with the aim to eventually locate the site of injury (neuron, glia, or myelin).
Quantitative analysis of peptides from myelin basic protein
binding to the MHC class II protein, I-AU, which confers susceptibility to experimental allergic encephalomyelitis.
ATX-MS-1467 consists of four synthetic peptides that mimic naturally occurring peptides derived from human Myelin Basic Protein
(MBP), a key autoantigen in multiple sclerosis.
For pragmatic reasons it is thus sufficient to select T-cells, which either target the spinal cord (such as myelin basic protein
reactive T-cells) or the spinal cord and optic nerves (such as MOG reactive T-cells).