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orlistat |
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orlistat /or·li·stat/ (or´lĭ-stat) an inhibitor of gastrointestinal lipases that prevents the digestion, and therefore absorption, of dietary fat; used in the treatment of obesity. Orlistat A drug that inhibits lipase. Mentioned in: Weight Loss Drugs orlistat, a lipase inhibitor. indication It is used to manage obesity. contraindications Malabsorption syndrome, cholestasis, and known hypersensitivity to this drug prohibit its use. adverse effects Adverse effects include back pain, arthritis, myalgia, tendinitis, depression, anxiety, dizziness, headache, fatigue, nausea, vomiting, abdominal pain, infectious diarrhea, rectal pain, tooth disorder, urinary tract infection, vaginitis, menstrual irregularity, influenza, upper respiratory infection, eye-ear-nose-throat symptoms, dry skin, and rash. Common side effects include insomnia, oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, and fecal incontinence. Orlistat (ôr´listat), n brand name: Xenical; drug class: lipase inhibitors; action: interferes with the body's ability to digest fat but may cause gas and oily bowel movements; uses: reduction in fat absorption for weight loss. orlistat Alli, Xenical Pharmacologic class: GI lipase inhibitor Therapeutic class: Weight control drug Pregnancy risk category B ActionInhibits absorption of dietary fats in stomach and small intestine AvailabilityCapsules: 60 mg (over-the-counter drug), 120 mg ⊘Indications and dosages ➣ Obesity management (in conjunction with reduced-calorie diet); to reduce risk of regaining after weight loss Adults: 120 mg (Xenical) P.O. t.i.d. with each meal containing fat ➣ Weight loss in overweight adults (in conjunction with reduced-calorie and low-fat diet) Adults ages 18 and older: 60 mg (Alli) P.O. t.i.d. with each meal containing fat Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Know that organic causes of obesity should be ruled out before therapy starts.
Adverse reactionsCNS: Xenical: dizziness, headache, fatigue, insomnia, depression, anxiety EENT: Xenical: ear, nose, and throat symptoms GI: fecal urgency, flatus with discharge, oily or increased bowel movements, oily spotting, fecal incontinence GU: Xenical: urinary tract infection (UTI), vaginitis, menstrual irregularities Musculoskeletal: Xenical: back pain, arthritis, myalgia, tendinitis Respiratory: Xenical: upper or lower respiratory infection Skin: Xenical: dry skin, rash Other: Xenical: dental pain, tooth disorder, influenza InteractionsDrug-drug. Beta-carotene, fat-soluble vitamins: reduced vitamin absorption Cyclosporine: reduced cyclosporine blood level (Xenical) Pravastatin: increased lipid-lowering effects (Xenical) Warfarin: altered coagulation parameters Patient monitoring• Watch for signs and symptoms of UTI, respiratory infection, and EENT disorders. Patient teaching• Instruct patient to take with meals as directed. Tell him he may omit a dose if he misses a meal or eats a fat-free meal. orlistat How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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