MYH6

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MYH6

A gene on chromosome 14q12 that encodes a heavy chain of myosin and is thus involved in cytokinesis, cell shape and specialised functions—e.g., secretion and capping.
 
Molecular pathology
MYH6 mutation causes familial hypertrophic cardiomyopathy and atrial septal defect 3.
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References in periodicals archive ?
MyHC I expression level in porcine myocytes was increased by 1 and 5 [micro]g/mL ethyl acetate extraction of the TCMF (p<0.
Zhang et al [38] observed that pigs with a higher PGC-1[alpha] mRNA expression level showed a greater expression level of MyHC I, MyHC IIa, and MyHC IIx mRNA, as well as a lower expression level of MyHC IIb mRNA.
The decreased percentage in type IIB fibers in the psoas major muscle was directly related to the comprehensive effectiveness of the decline of the MyHC IIb mRNA expression level and the increase in the MyHC IIx mRNA expression level.
As shown in the experiment, porcine myocytes were identified by proliferation and differentiation within 5 days with a nearly 80% differentiation fusion index manifested in an abundance of discrete MyHC [47].
Analysing mRNA transcriptions of four adult MyHC genes in longissimus muscle
Standard mRNA fragments for MyHC I, Ila, IIx and Ilb were produced as described by Hu et al.
The supernatant was used to measure total protein concentration as described in the above section "Analyzing protein expressions of four MyHC genes in LM".
Dynamics changes of MyHC I, Ila, IIx, and IIb protein expressions
We first examined changes in the expression of the myosin heavy chain isoforms MyHC I, MyHC IIA, MyHC IIB and MyHC IIX, following 8 weeks of moderate or high intensity treadmill exercise, using SDS-PAGE.
Aerobic exercise influences the expression of MyHC isoforms in the skeletal soleus muscle
Studies have shown that exercise can induce the transformation of skeletal muscle fibers from fast twitch to the slow type, accompanied by the interconversion of MyHC isoforms.
There is experimental evidence that specific combinations of NFAT family members are involved in the interconversion of fast and slow MyHC isoforms.