genetic load

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Related to Mutational load: Genetic burden

ge·net·ic load

the aggregate of more or less harmful genes that are carried, mostly hidden, in the genome that may be transmitted to descendants and cause morbidity and disease; in classic genetic dynamics, genetic load may be seen as undischarged genetic debts that result from previous mutations, each of which is supposed to exact an average number of lethal equivalents dependent only on the pattern of inheritance, regardless of how mild or severe the phenotype may be.

genetic load

n.
1. The relative difference between the theoretically most fit genotype within a population and the average genotype.
2. The aggregate of deleterious genes that are carried, mostly hidden, in the genomes of a population and may be transmitted to descendants.

genetic load

the average number of accumulated detrimental genes per individual within a population, including those caused by mutation and selection within a recent generation and those inherited from ancestors. Genetic load is expressed in lethal equivalents.

ge·net·ic load

(jĕ-net'ik lōd)
The aggregate of more or less harmful genes that are carried, mostly hidden, in the genome and may be transmitted to descendants and cause disease.

genetic load

The totality of abnormalities caused in each generation by defective genetic material carried in the human gene pool.

genetic load

a measurement of the amount of deleterious genes in a population, calculated as the average number of lethal equivalents per individual.
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References in periodicals archive ?
Not only were we able to assess the KRAS mutational load, we were also able to identify the presence of minor alleles consistently.
The evidence for high nucleotide polymorphism in the Pacific oyster is interesting in light of recent experimental evidence for a high mutational load in this species (Launey & Hedgecock 2001, Bucklin 2002).
Results of this study validate that high KRAS mutation levels at diagnosis, as well as increases in mutational load over time, significantly correlate with poor prognoses for patients diagnosed with pancreatic cancer," stated Mark Erlander, Ph.
Tracking the mutation using urinary cell-free DNA provides a window to see how the disease is responding, and these new data show that regardless of which drug is used, treatment response over time correlates well with BRAF V600E mutational load.
Secondary objectives include correlating quantitative EGFR mutational load over time with tumor burden, and demonstrating detection of the resistant EGFR T790M mutation prior to clinical or radiographic progression in lung cancer patients treated with tyrosine kinase inhibitor therapy.