muscle fatigue

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mus·cle fa·tigue

(mus'ĕl fă-tēg')
A state of exhaustion or loss of strength and/or muscle endurance following strenuous activity associated with the accumulation of lactic acid in muscles.

muscle fatigue

The reduced capacity of a muscle to perform work as a result of repeated contractions and accumulation of lactic acid in anaerobic cell respiration. The fatigue may be partial or complete.
See also: fatigue

muscle fatigue

impairment of muscle force production or of shortening speed resulting from repeated and/or prolonged activity. Causes vary greatly according to the nature and duration of the effort. In all cases they appear to consist principally in disturbances of intramuscular biochemistry, differing substantially between circumstances. However, the possibility of contributory neural factors, resulting in reduced muscle activation, should never be overlooked. Note that cytoplasmic ATP concentrations never fall to less than about half resting levels in living muscle fibres (radical ATP depletion would lead to rigor, not weakness). See also central fatigue, glycogen.

mus·cle fa·tigue

(mus'ĕl fă-tēg')
A state of exhaustion or loss of strength and/or muscle endurance following strenuous activity associated with the accumulation of lactic acid in muscles.
References in periodicals archive ?
It is characterised by slow onset of action, characteristically over many years, and atypical features such as distal muscle weakness, asymmetrical involvement, muscle atrophy and a poor response to steroids.
A 33-year-old nondiabetic, nonhypertensive woman presented with a complaint of proximal muscle weakness of all four limbs for the past two months.
Through this collaboration, we intend to jointly investigate the potential role that CK-2127107 and follow-on skeletal muscle activators can play in providing functional improvements in patients with diseases characterized by muscle weakness and fatigue.
He described a patient with proximal muscle weakness, eyelid changes muscle biopsy evidence of myositis as well as coasting gastric carcinoma.
On neurological examination she had bilateral ptosis, bilateral asymmetrical facial weakness (with involvement of the forehead) and generalised proximal muscle weakness which was characterised by fatigability.
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The Bahrain Ministry of Health approved Novartis-made drug Gilenya (fingolimod) for use in relapsing remitting form of MS that affects around two-thirds of those diagnosed with the disease, which causes muscle weakness, problems with co-ordination and impaired concentration.
Caused by a gene fault, it leads to progressive muscle weakness.
Skeletal muscle weakness is a common finding in patients with chronic heart failure (CHF).
Both people in the latest Ventura County cases are between 40 and 50 years old and have suffered from fevers, headaches, body rashes, muscle weakness and fatigue, officials said.
INTERACTIVE CDs are being given to Merseyside opticians to help them diagnose Myasthenia Gravis, a muscle weakness illness which has no known cure and which can prove fatal.
While living on a farm in Ireland two years ago I was suffering from extreme insomnia and muscle weakness caused by an insect spray (parathion).