multiple primary malignancy syndrome

(redirected from Multiple primary cancers-Werthamer criteria)

multiple primary malignancy syndrome

The rare (seen in less than 1% of patients) finding of three or more primary malignancies in the same patient.

Multiple primary cancers—Werthamer criteria  
1. The malignancies must be primary in different organs. 
2. Paired-organ (e.g., breast, kidney) malignancies (synchronous or metachronous) are viewed as a single primary. 
3. Multiple malignant tumours originating in one organ are viewed as a single primary. 
4. The lower intestine and uterus (with adnexa) are each considered single organs. 
5. The malignant nature of the lesions must be confirmed histologically. 
6. The lesion should be histologically proven to be non-metastatic (may not be possible).
 
Additional criterion—The malignancy should not have been induced by chemotherapy or radiation.

multiple primary malignancy syndrome

Oncology The rare–
< 1% of Pts–finding of 3+ primary malignancies, a 'syndrome' defined by Werthamer–Maximum known MPMs in 1 Pt 6
Multiple primary cancers–Werthamer criteria  
1. The malignancies must be primary in different organs
.
2. Paired-organ–breast, kidney malignancies–synchronous or metachronous are considered to be a single primary
.
3. Multiple malignant tumors originating in the same organ are viewed as a single primary
.
4. The lower intestine and uterus–with adnexae, are each considered single organs
.
5. The malignant nature of the lesions must be confirmed histologically
.
6. The lesion should be histologically proven to be non-metastatic–this may be impossible
Additional criterion–The malignancy should not have been induced by chemo- or RT
.
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