Multiple endocrine neoplasia type 1


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MEN 1

An inherited neoplasia syndrome characterised by: parathyroid hyperplasia (95%), pituitary adenoma (10%), pancreatic islet hyperplasia, adenoma or carcinoma, and/or adrenal cortical hyperplasia, adenoma and carcinoid tumours.

Molecular pathology
Mutation of MEN1 on chromosome 11.

Multiple endocrine neoplasia type 1 (MEN-1)

An inherited condition marked by multiple malignancies of the pituitary gland, parathyroid gland, and islet cells of the pancreas. About half of MEN-1 patients with pancreatic islet cell tumors will have gastrinomas, gastrin-producing tumors that lead to ulcer disease.
Mentioned in: Gastrinoma
References in periodicals archive ?
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma.
D, Two neuroendocrine tumors in a patient with multiple endocrine neoplasia type 1.
Somatic mutations of multiple endocrine neoplasia type 1 gene in the sporadic endocrine tumors.
Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas.
Multiple leiomyomas of the esophagus, lung, and uterus in multiple endocrine neoplasia type 1.
8) Similar to multiple endocrine neoplasia type 1 (MEN1) syndrome, patients with VHL disease can be associated with precursor lesions including ductuloinsular complexes (nesidioblastosis), islet dysplasia (referring to normal-sized or slightly enlarged islets <0.
Similar to multiple endocrine neoplasia type 1 syndrome, VHL disease can be associated with precursor lesions including ductuloinsular complexes, islet dysplasia, pancreatic microadenomas (A; asterisk), and peliosis (B) of the nontumorous islets.
Disorders such as familial hyperparathyroidism, multiple endocrine neoplasia type 1 (MEN 1), and hyperparathyroidism-jaw tumor syndrome can, if left unchecked, result in OFC.
These include multiple endocrine neoplasia type 1 (MEN1 gene), von Hippel-Lindau (VHL gene), neurofibromatosis type 1 (NF1 gene) and tuberous sclerosis (TSC1 and TSC2 genes).
Pancreatic endocrine neoplasms are usually sporadic but may be part of hereditary syndromes mostly including multiple endocrine neoplasia type 1 (MEN-1) and, more rarely, von Hippel-Lindau (VHL) syndrome, neurofibromatosis type 1 (NF1), and tuberous sclerosis complex (TSC).

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