Multiple endocrine neoplasia type 1


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MEN 1

An inherited neoplasia syndrome characterised by: parathyroid hyperplasia (95%), pituitary adenoma (10%), pancreatic islet hyperplasia, adenoma or carcinoma, and/or adrenal cortical hyperplasia, adenoma and carcinoid tumours.

Molecular pathology
Mutation of MEN1 on chromosome 11.

Multiple endocrine neoplasia type 1 (MEN-1)

An inherited condition marked by multiple malignancies of the pituitary gland, parathyroid gland, and islet cells of the pancreas. About half of MEN-1 patients with pancreatic islet cell tumors will have gastrinomas, gastrin-producing tumors that lead to ulcer disease.
Mentioned in: Gastrinoma
References in periodicals archive ?
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma.
Somatic mutations of multiple endocrine neoplasia type 1 gene in the sporadic endocrine tumors.
Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas.
It is based in part on the booklet, "Understanding Multiple Endocrine Neoplasia Type 1," published by the NIH Clinical Center's Communications Office.
The multiple endocrine neoplasia Type 1 (MEN-1) syndrome is characterized by the occurrence of parathyroid, endocrine pancreatic, and anterior pituitary tumors, and, to a lesser extent, other endocrine tumors (eg, carcinoid or adrenal tumors) in a single patient or in a familial context.
Germilne mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states.
Although genetic abnormalities--specifically those in the multiple endocrine neoplasia Type 1 gene--have been reported in some cases, environmental factors have not been well documented.
Pancreatic endocrine neoplasms are usually sporadic but may be part of hereditary syndromes mostly including multiple endocrine neoplasia type 1 (MEN-1) and, more rarely, von Hippel-Lindau (VHL) syndrome, neurofibromatosis type 1 (NF1), and tuberous sclerosis complex (TSC).
Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome.

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