multidrug resistance

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1. opposition, or counteracting force, as opposition of a conductor to passage of electricity or other energy or substance.
2. the natural ability of a normal organism to remain unaffected by noxious agents in its environment; see also immunity.
3. in psychology or psychiatry, conscious or unconscious defenses against change, preventing repressed material from coming into awareness; they can take such forms as forgetfulness, evasions, embarrassment, mental blocks, denial, anger, superficial talk, intellectualization, or intensification of symptoms. It occurs because the blocked association or understanding would be too threatening to face at this point in the therapy; identification of what point the resistance comes at can be an important indicator of the patient's unconscious patterns.
airway resistance the opposition of the tissues of the air passages to air flow: the mouth-to-alveoli pressure difference divided by the rate of air flow. Symbol RA or RAW.
androgen resistance resistance of target organs to the action of androgens, resulting in any of a spectrum of defects from a normal male phenotype in which men have normal genitalia but infertility to complete androgen resistance in which the individual has a female phenotype. Complete androgen resistance is an extreme form of male pseudohermaphroditism in which the individual is phenotypically female but is of XY chromosomal sex; there may be rudimentary uterus and tubes, but the gonads are typically testes, which may be abdominal or inguinal in position. Called also testicular feminization and testicular feminization syndrome. Incomplete androgen resistance is any of various forms less than the complete type, manifested by a male phenotype with various degrees of ambiguous genitalia such as hypospadias and a small vaginal pouch, a hooded phallus, or a bifid scrotum that may or may not contain gonads.
drug resistance the ability of a microorganism to withstand the effects of a drug that are lethal to most members of its species.
insulin resistance see insulin resistance.
multidrug resistance (multiple drug resistance) a phenomenon seen in some malignant cell lines: cells that have developed natural resistance to a single cytotoxic compound are also resistant to structurally unrelated chemotherapy agents. Called also cross-resistance.
peripheral resistance resistance to the passage of blood through the small blood vessels, especially the arterioles.
pulmonary vascular resistance the vascular resistance of the pulmonary circulation; the difference between the mean pulmonary arterial pressure and the left atrial filling pressure divided by the cardiac output. Called also total pulmonary vascular resistance.
total peripheral resistance the vascular resistance of the systemic circulation: the difference between the mean arterial pressure and central venous pressure divided by the cardiac output.
total pulmonary resistance (total pulmonary vascular resistance) pulmonary vascular resistance.
vascular resistance the opposition to blood flow in a vascular bed; the pressure drop across the bed divided by the blood flow, conventionally expressed in peripheral resistance units. Symbol R or R.

mul·ti·drug re·sis·tance (MDR),

the insensitivity of various tumors to a variety of chemically related anticancer drugs; mediated by a process of inactivating the drug or removing it from the target tumor cells.

multidrug resistance

1 the resistance of tumor cells to more than one chemotherapeutic agent. Resistance may be aided by a P-glycoprotein transmembrane pump that lowers the concentration of drugs in the cell.
2 the resistance of bacteria, especially Mycobacterium tuberculosis, against more than two of the antibiotics that were once effective.

multidrug resistance,

n the adaptation of tumor cells or infectious agents to resist chemotherapeutic agents.
References in periodicals archive ?
The use of short regimens for treatment of multidrug resistant tuberculosis [cited 2015 May 20].
Foster City, CA) has patented a method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated formulation of aztreonam lysinate delivered as an aerosol or dry powder formulation.
MONTREAL -- Short-course therapy with oral gemifloxacin is effective for the treatment of mild to moderate community-acquired pneumonia, including that caused by multidrug resistant Streptococcus pneumoniae, a study has shown.
The license applies to certain novel agents that will be developed for the treatment of multidrug resistant tumors.
OTCBB: SBFM), a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has completed a cytotoxicity study of its lead compound, Adva-27a, in H69AR, a Multidrug Resistant Small Cell Lung Cancer cell line.
Optimal antibiotic therapy for multidrug resistant (MDR) Acinetobacter baumannii.
In addition, the mean length of hospital stay was significantly higher in the multidrug resistant group (27 days) compared with the other two groups (20 days and 19 days, respectively).
Sunshine Biopharma's recently announced preclinical results showed that Adva-27a has an excellent pharmacokinetics profile in rats and remarkable cytotoxic activity against a variety of cancer cells, particularly multidrug resistant Breast Cancer cells.
OTCBB: SBFM), which has designed and synthesized a new compound, Adva-27a, that acts as an inhibitor of multidrug resistant breast cancer cells in vitro, today announced that it will be presenting new scientific data at the American Association for Cancer Research Meeting March 31-April 4, 2012, in Chicago, Illinois, together with its research collaborator, Binghamton University, a State University of New York.
An isolate was considered multidrug resistant if the isolate was resistant to [greater than or equal to] 4 antimicrobial agents.
Levofloxacin is superior to ofloxacin when used as part of a multidrug regimen for the treatment of multidrug resistant TB, findings from a retrospective study suggest.

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