multidrug resistance

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1. opposition, or counteracting force, as opposition of a conductor to passage of electricity or other energy or substance.
2. the natural ability of a normal organism to remain unaffected by noxious agents in its environment; see also immunity.
3. in psychology or psychiatry, conscious or unconscious defenses against change, preventing repressed material from coming into awareness; they can take such forms as forgetfulness, evasions, embarrassment, mental blocks, denial, anger, superficial talk, intellectualization, or intensification of symptoms. It occurs because the blocked association or understanding would be too threatening to face at this point in the therapy; identification of what point the resistance comes at can be an important indicator of the patient's unconscious patterns.
airway resistance the opposition of the tissues of the air passages to air flow: the mouth-to-alveoli pressure difference divided by the rate of air flow. Symbol RA or RAW.
androgen resistance resistance of target organs to the action of androgens, resulting in any of a spectrum of defects from a normal male phenotype in which men have normal genitalia but infertility to complete androgen resistance in which the individual has a female phenotype. Complete androgen resistance is an extreme form of male pseudohermaphroditism in which the individual is phenotypically female but is of XY chromosomal sex; there may be rudimentary uterus and tubes, but the gonads are typically testes, which may be abdominal or inguinal in position. Called also testicular feminization and testicular feminization syndrome. Incomplete androgen resistance is any of various forms less than the complete type, manifested by a male phenotype with various degrees of ambiguous genitalia such as hypospadias and a small vaginal pouch, a hooded phallus, or a bifid scrotum that may or may not contain gonads.
drug resistance the ability of a microorganism to withstand the effects of a drug that are lethal to most members of its species.
insulin resistance see insulin resistance.
multidrug resistance (multiple drug resistance) a phenomenon seen in some malignant cell lines: cells that have developed natural resistance to a single cytotoxic compound are also resistant to structurally unrelated chemotherapy agents. Called also cross-resistance.
peripheral resistance resistance to the passage of blood through the small blood vessels, especially the arterioles.
pulmonary vascular resistance the vascular resistance of the pulmonary circulation; the difference between the mean pulmonary arterial pressure and the left atrial filling pressure divided by the cardiac output. Called also total pulmonary vascular resistance.
total peripheral resistance the vascular resistance of the systemic circulation: the difference between the mean arterial pressure and central venous pressure divided by the cardiac output.
total pulmonary resistance (total pulmonary vascular resistance) pulmonary vascular resistance.
vascular resistance the opposition to blood flow in a vascular bed; the pressure drop across the bed divided by the blood flow, conventionally expressed in peripheral resistance units. Symbol R or R.

mul·ti·drug re·sis·tance (MDR),

the insensitivity of various tumors to a variety of chemically related anticancer drugs; mediated by a process of inactivating the drug or removing it from the target tumor cells.

multidrug resistance

1 the resistance of tumor cells to more than one chemotherapeutic agent. Resistance may be aided by a P-glycoprotein transmembrane pump that lowers the concentration of drugs in the cell.
2 the resistance of bacteria, especially Mycobacterium tuberculosis, against more than two of the antibiotics that were once effective.

multidrug resistance,

n the adaptation of tumor cells or infectious agents to resist chemotherapeutic agents.
References in periodicals archive ?
Binary and ordinal (after testing the parallel lines assumption) logistic regression analyses were used to identify variables independently associated with fluconazole, caspofungin, and multidrug resistance.
Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin resistant human myelogenous leukemia (K562/DOX) cells.
SDZ PSC 833, a non-immunosuppressive cyclosporine: its potency in overcoming P-glycoprotein-mediated multidrug resistance of murine leukemia.
Reversal of ABCG2-mediated multidrug resistance by human cathelicidin and its analogs in cancer cells.
Leading organisations in Multidrug Resistance research include:
As one of many clinical anticancer drugs that may induce multidrug resistance, Docetaxel (DOC) has anti-mitotic properties through the binding to microtubules (MTs) and prevention of depolymerization and stabilization of microtubules (Fitzpatrick and Wheeler, 2003).
The epidermal growth factor receptor (EGFR) has also been associated with multidrug resistance (Biedler and Spengler, 1994; Efferth et al.
With the introduction of the FLIPR Multidrug Resistance Assay Kit, live-cell assays can be used to rapidly screen MDR pump inhibitors in high-throughput screening applications.
Contract award: Successive delivery of materials laboratory within the EU project "The Role of multidrug resistance transporters in pharmacokinetics and toxicology - in vitro tests in the pharmaceutical and clinical practice.
Based on our in vitro and in vivo results, diallyl polysulfides (DAS, DADS and DATS) affected the gene expression of the multidrug resistance in colo 205 human colon cancer cells in vitro and in vivo.
Multidrug resistance was defined as resistance to [greater than or equal to] 5 antimicrobial drugs.

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