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moyamoya disease
(redirected from Moyamoya)

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moyamoya disease
[moi′əmoi′ə]
a cerebrovascular disorder in which the main cerebral arteries at the base of the brain are replaced by a fine network of vessels. It is caused by progressive stenosis of the large-caliber vessels and development of collateral network. It tends mainly to affect Japanese children and young adults and is characterized by convulsions, hemiplegia, mental retardation, and subarachnoid hemorrhage. Patients who survive into adulthood are susceptible to massive intracerebral hemorrhage caused by rupture of the fragile network of new vessels. Few patients live beyond 30 years of age.


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The research team led by Dianna Milewicz, professor and director of the Division of Medical Genetics at The University of Texas Medical School at Houston has found that mutations in n smooth muscle alpha-actin (ACTA2) cause early onset coronary artery disease, stroke and moyamoya disease, along with thoracic aortic aneurysms and dissections.
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Rarely, an occlusive vasculopathy similar to moyamoya disease may occur [66].
Neuroimaging of CNS involvement in HIV by Descamps, M.J.L.; Hyare, H.; Zerizer, I.; Jager, H.R. / Journal of HIV Therapy
 
 
 
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