Alignment of the deduced amino acid sequence of the L gene with the L gene of various other viruses belonging to the Mononegavirales
order by using MAFFT version 7 (http://mafft.
1) The rabies virus is a negative strand RNA-virus belonging to the genus Lyssavirus, family Rhabdoviridae of the order Mononegavirales
Board 24 PHYLOGENY OF THE MONONEGAVIRALES
VSV is a negative-strand, non-segmented RNA virus from the order Mononegavirales
that has been redesigned to enable delivery of vaccine immunogens.
In addition, the RNA editing site (AAAAGG) for the processing of V and W proteins conserved in the phosphoprotein gene sequences of Hendra virus and Nipah virus was found, and 6 conserved domains within the L proteins of the order Mononegavirales
(8) were found in the MojV L protein.
Phylogenetic relationships among members of the negative-sense RNA viral order Mononegavirales
were examined using sequences of the structural glycoprotein.
are enveloped, single-stranded, negative-sense RNA viruses that comprise a large and diverse family in the order Mononegavirales
and infect arthropods, plants, fish, and mammals.
The etiologic agent, Borna disease virus (BDV), belongs to the order Mononegavirales
, which is composed of many reservoir-bound, highly pathogenic, and zoonotic viruses.
However, rabies still remains a public health problem in these countries because of natural circulation of bat-specific viruses (order Mononegavirales
, family Rhabdoviridae, genus Lyssavirus) such as European bat lyssavirnses (EBLVs).
As the prototype and only known member of the family Bornaviridae in the order Mononegavirales
(nonsegmented, negative-strand RNA viruses), BDV is atypical in its nuclear localization of transcription, alternative splicing, and differential use of initiation and termination signals.
Presently, 7 species are recognized within the genus Lyssavirus (order Mononegavirales
, family Rhabdoviridae): Rabies virus (RABV), Lagos bat virus (LBV), Mokola virus (MOKV), Duvenhage virus (DUVV), European bat lyssavirus, types 1 and 2, and Australian bat lyssavirus.
Borna disease (BD) is a severe immunopathologic disorder of the central nervous system induced by infection with Borna disease virus (BDV), the prototype of a new virus family, Bornaviridae, within the order Mononegavirales