monoclonal

(redirected from Monoclonals)
Also found in: Dictionary, Thesaurus, Encyclopedia.

monoclonal

 [mon″o-klo´nal]
derived from a single cell; pertaining to a single clone.

mon·o·clo·nal

(mon'ō-klō'năl),
In immunochemistry, pertaining to a protein from a single clone of cells, all molecules of which are the same; for example, in the case of Bence Jones protein, the chains are all κ or λ.

monoclonal

/mono·clo·nal/ (-klōn´al)
1. derived from a single cell.
2. pertaining to a single clone.

monoclonal

(mŏn′ə-klō′nəl)
adj.
Derived as clones from a single cell or produced by clones of a single cell: a monoclonal tumor.
n.
A monoclonal product, such as a monoclonal antibody.

monoclonal

[mon′əklō′nəl]
Etymology: Gk, monos + klon, twig
pertaining to or designating a group of identical cells or organisms derived from a single cell or organism. Compare polyclonal.

monoclonal

adjective Referring to a single clone of cells.

mon·o·clo·nal

(mon'ō-klōn'ăl)
immunochemistry Pertaining to a protein from a single clone of cells, all molecules of which are the same.

monoclonal

Of a group of cells derived from a single cell, all having the same GENOTYPE. Of a single CLONE of cells.

Monoclonal

Identical cells or proteins; cells (clones) derived from a single, genetically-distinct cell, or proteins produced by these cells.

monoclonal

derived from a single cell; pertaining to a single clone.

monoclonal antibodies
identical immunoglobulin molecules formed by a single clone of plasma cells; may occur naturally in plasma cell myelomas or in vitro by the fusion of an antibody producing B lymphocyte with a non-antibody-producing myeloma B cell. The fused heterokaryon has the properties of immortality and production of a monoclonal antibody. For the most part, monoclonal antibodies are made in mouse systems.
monoclonal gammopathy
see monoclonal gammopathy.
References in periodicals archive ?
Table 6: Leading Products in the Global Oncology Monoclonal Antibodies Market (2008E): Percentage Share Breakdown of Sales for Avastin, Herceptin, Rituxan, Erbitux, and Others (includes corresponding Graph/Chart) II-7
Table 8: Worldwide MAb Market by Product Type (2008): Percentage Share Breakdown for Chimeric, Humanized, Human and Murine (includes corresponding Graph/Chart) II-19 Murine Monoclonal Antibodies II-19 Humanized Antibodies/ CDR Grafted Antibodies II-20 Murine Vs Human Monoclonal Antibodies II-20 Chimeric Antibodies: Show Lesser Antigenicity II-21 Fully Human Antibodies II-21 Bispecific Antibodies II-21 Certain Limitations Do Exist II-21 Advantages of MAbs II-22 Advantages and Limitations of MAb Technologies II-22
Diagnostic Applications of Monoclonal Antibodies II-23
Monoclonal Antibody-Based Therapeutics II-26 Evolution of Therapeutic Antibody Products II-26 Advantages of Therapeutic Monoclonal Antibodies II-26 Current Scenario in Monoclonal Antibody Therapeutics Market II-27
Product Launches and Developments II-47 Amgen Introduces Vectibix II-47 Trevigen Introduces Mouse Monoclonal Antibody II-47 UCB Receives FDA Approval for Cimzia[R] II-47 GSK's Tykerb Receives FDA Approval II-47 Dr.
Table 10: World Recent Past, Current & Future Market Analysis for Monoclonal Antibody Based Products by Geographic Region - US, Canada, Japan, Europe, and Rest of World Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2010 (includes corresponding Graph/Chart) II-91
If you can get human monoclonal antibody production totally in vitro," he says, "it's really a major advance.
Just as the development of humanized monoclonal antibodies represented a significant medical advance, we believe the development of humanized polyclonal antibodies, if successful, will prove to be a watershed event in medical science.
Also, Buelow's research team worked on Thymoglobulin(R), the leading polyclonal antibody product in solid organ transplantation, and outselling humanized monoclonal antibodies like Simulect(R) and Zenapax(R).
Chiron/Miles' Bay x-1351, a monoclonal that targets tumor necrosis factor (TNF), could reach the market within this time frame too and generate $135 million in revenue by 1997.
Human monoclonal antibodies offer an obvious solution.