monoclonal

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monoclonal

 [mon″o-klo´nal]
derived from a single cell; pertaining to a single clone.

mon·o·clo·nal

(mon'ō-klō'năl),
In immunochemistry, pertaining to a protein from a single clone of cells, all molecules of which are the same; for example, in the case of Bence Jones protein, the chains are all κ or λ.

monoclonal

/mono·clo·nal/ (-klōn´al)
1. derived from a single cell.
2. pertaining to a single clone.

monoclonal

(mŏn′ə-klō′nəl)
adj.
Derived as clones from a single cell or produced by clones of a single cell: a monoclonal tumor.
n.
A monoclonal product, such as a monoclonal antibody.

monoclonal

[mon′əklō′nəl]
Etymology: Gk, monos + klon, twig
pertaining to or designating a group of identical cells or organisms derived from a single cell or organism. Compare polyclonal.

monoclonal

adjective Referring to a single clone of cells.

mon·o·clo·nal

(mon'ō-klōn'ăl)
immunochemistry Pertaining to a protein from a single clone of cells, all molecules of which are the same.

monoclonal

Of a group of cells derived from a single cell, all having the same GENOTYPE. Of a single CLONE of cells.

Monoclonal

Identical cells or proteins; cells (clones) derived from a single, genetically-distinct cell, or proteins produced by these cells.

monoclonal

derived from a single cell; pertaining to a single clone.

monoclonal antibodies
identical immunoglobulin molecules formed by a single clone of plasma cells; may occur naturally in plasma cell myelomas or in vitro by the fusion of an antibody producing B lymphocyte with a non-antibody-producing myeloma B cell. The fused heterokaryon has the properties of immortality and production of a monoclonal antibody. For the most part, monoclonal antibodies are made in mouse systems.
monoclonal gammopathy
see monoclonal gammopathy.
References in periodicals archive ?
Table 3: Leading Drugs in the Global Therapeutic Monoclonal Antibodies Market (2006): Percentage Breakdown of Dollar Sales for Remicade, Rituxan, Herceptin, Avastin, Humira, Erbitux, Synagis, Xolair and Others (includes corresponding Graph/Chart) II-6
Table 4: Monoclonal Antibody Based Products Market (2004): Percentage Breakdown of Leading Manufacturers by Sales for Genentech, Johnson & Johnson, Roche, Abbott, MedImmune, Schering Plough, Eli Lilly, and Others (includes corresponding Graph/Chart) II-6
Table 5: Monoclonal Antibody Based Products Market (2004): Percentage Breakdown of Leading Drugs by Sales for Remicade, Rituxan, Herceptin, Synagis, Humira, Avastin, ReoPro, Erbitux, Xolair, and Others (includes corresponding Graph/Chart) II-6
Table 6: Leading Products in the Global Oncology Monoclonal Antibodies Market (2008E): Percentage Share Breakdown of Sales for Avastin, Herceptin, Rituxan, Erbitux, and Others (includes corresponding Graph/Chart) II-7
Table 8: Worldwide MAb Market by Product Type (2008): Percentage Share Breakdown for Chimeric, Humanized, Human and Murine (includes corresponding Graph/Chart) II-19 Murine Monoclonal Antibodies II-19 Humanized Antibodies/ CDR Grafted Antibodies II-20 Murine Vs Human Monoclonal Antibodies II-20 Chimeric Antibodies: Show Lesser Antigenicity II-21 Fully Human Antibodies II-21 Bispecific Antibodies II-21 Certain Limitations Do Exist II-21 Advantages of MAbs II-22 Advantages and Limitations of MAb Technologies II-22
Diagnostic Applications of Monoclonal Antibodies II-23
Monoclonal Antibody-Based Therapeutics II-26 Evolution of Therapeutic Antibody Products II-26 Advantages of Therapeutic Monoclonal Antibodies II-26 Current Scenario in Monoclonal Antibody Therapeutics Market II-27
Product Launches and Developments II-47 Amgen Introduces Vectibix II-47 Trevigen Introduces Mouse Monoclonal Antibody II-47 UCB Receives FDA Approval for Cimzia[R] II-47 GSK's Tykerb Receives FDA Approval II-47 Dr.
Table 10: World Recent Past, Current & Future Market Analysis for Monoclonal Antibody Based Products by Geographic Region - US, Canada, Japan, Europe, and Rest of World Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2010 (includes corresponding Graph/Chart) II-91
Table 11: World Long-term Projections for Monoclonal Antibody Based Products by Geographic Region - US, Canada, Japan, Europe, and Rest of World Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-92
Table 12: World 10-Year Perspective for Monoclonal Antibody Based Products by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-93
If you can get human monoclonal antibody production totally in vitro," he says, "it's really a major advance.