monoclonal gammopathy of undetermined significance

Monoclonal gammopathy of undetermined significance (MGUS)

Common condition in which M-protein is present, but there are no tumors or other symptoms of disease.

Mentioned in: Multiple Myeloma

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monoclonal gammopathy of undetermined significance

Benign monoclonal gammopathy, MGUS Hematology A condition defined by lab criteria Criteria Normal Hb, serum albumin < 20 g/L–US: < 2 g/dl, an M-component, no Bence-Jones proteinuria, < 5% plasma cells in the BM, no osteolytic lesions; MGUS differs from myeloma in that the plasma cells in the BM are < 20%, and the ESR and monoclonal component are lower Prognosis 20-40% of MGUS progress to malignant monoclonality Management Plasma exchange may be improve the neuropathy associated with IgA or IgG MGUS

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Patient discussion about monoclonal gammopathy of undetermined significance.

Q. Does anyone know anything about MGUS?

A. MGUS is a condition that affects a type of white blood cell known as a plasma cell. Plasma cells are a type of white blood cell that produce special proteins, known as antibodies or immunoglobulins. These antibodies circulate in the blood, ready to attack any viruses and bacteria that may be present in the body.
When an abnormally large amount of one particular antibody is produced, this is called monoclonal gammopathy. All the antibodies are identical.