monoclonal gammopathy of undetermined significance

(redirected from Monoclonal gammopathies, benign)

monoclonal gammopathy of undetermined significance

a paraproteinemia (an abnormal gammaglobulin, typically with λ light chain component) of less than 3 g/100 mL, which, at the time of discovery, is without apparent cause; specifically, there is no evidence of multiple myeloma or other malignant disorders.

monoclonal gammopathy of undetermined significance

Benign monoclonal gammopathy, MGUS Hematology A condition defined by lab criteria Criteria Normal Hb, serum albumin < 20 g/L–US: < 2 g/dl, an M-component, no Bence-Jones proteinuria, < 5% plasma cells in the BM, no osteolytic lesions; MGUS differs from myeloma in that the plasma cells in the BM are < 20%, and the ESR and monoclonal component are lower Prognosis 20-40% of MGUS progress to malignant monoclonality Management Plasma exchange may be improve the neuropathy associated with IgA or IgG MGUS

monoclonal gammopathy of undetermined significance

A condition featuring the presence of a monoclonal protein in people with no evidence, for a period of years, of clinical indications of multiple myeloma or other related disorders. In a proportion of cases, however, a malignant plasma cell disease develops.

Monoclonal gammopathy of undetermined significance (MGUS)

Common condition in which M-protein is present, but there are no tumors or other symptoms of disease.
Mentioned in: Multiple Myeloma

Patient discussion about monoclonal gammopathy of undetermined significance

Q. Does anyone know anything about MGUS?

A. MGUS is a condition that affects a type of white blood cell known as a plasma cell. Plasma cells are a type of white blood cell that produce special proteins, known as antibodies or immunoglobulins. These antibodies circulate in the blood, ready to attack any viruses and bacteria that may be present in the body.
When an abnormally large amount of one particular antibody is produced, this is called monoclonal gammopathy. All the antibodies are identical.

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