aureus Antibiotics (n = 36) (n = 12) (n = 6) S R S R S R Penicillin 30 6 8 4 6 0 Carbapenems 36 0 12 0 6 0 Quinolones 18 18 7 5 6 0 Monobactams
26 10 7 5 3 3 Cephalosporins 10 26 4 8 4 2 Aminoglycosides 18 18 10 2 6 0 Glycopeptides 0 36 0 12 6 0 Macrolides 0 36 0 12 2 4 Pseudomonas Proteus S.
They are plasmid encoded and hydro-lysecephalosporins and monobactams
The [beta]-lactam antibiotics include the cephalosporins, the monobactams
, the penems, the carbapenems, as well as penicillin.
ESBLs are also able to hydrolyze three and four generation cephalosporins and monobactams
Beta-lactamases are the bacterial enzymes produced by a number of bacteria that provide resistance to beta-lactam antibiotics which include penicillins, carbapenems, cephalosporins and monobactams
Sterile and high potency APIs, steroids, generics, monobactams
, boronic acids and controlled substances
Strategically, our acquisitions have helped us establish a vast and responsive global development and manufacturing network, an extensive portfolio of unique APIs that have high barriers to entry, and expanded technical capabilities in areas such as sterile API, fermentation and monobactams
that complement our organic business.
Enzymes that catalyze the cleavage of p-lactam rings in penicillins, cephalosporins, monobactams
, and carbapenems were first described by Abraham and Chain in 1940.
ESBLs are capable ofefficiently hydrolyzing penicillin, cephalosporin, the oxyimino group containingcephalosporins (cefotaxime, ceftazidime) and monobactams
(aztreonam) and wide range of class A ESBLs have been reported in Acinetobactersp.
3,5,16] Colistin is usually combined with sulbactam, cephalosporins, carbapenems, piperacillin-tazobactam, monobactams
, aminoglycosides, fluoroquinolones, rifampin, tetracyclines and tigecycline.
Like most carbapenemases, KPCs are enzymes which inactivate all beta-lactam antibiotics, including carbapenems, penicillins, cephalosporins and monobactams
Other [beta]-lactam antibiotics: [beta]-Lactamase inhibitors, carbapenems, and monobactams