molecular chaperone


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Related to molecular chaperone: Chaperone molecule

molecular chaperone

A protein that shapes other protein molecules so they can work optimally as receptors or can be secreted or cleared from cells.
See also: chaperone

molecular chaperone

see CHAPERONE.
References in periodicals archive ?
Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones.
He wants to exploit this natural system by developing a smaller version of the molecular chaperone that could be put into the bloodstream to leach excess Abeta from the brain.
The CytRx molecular chaperone portfolio includes three drug candidates, arimoclomol, iroxanadine and bimoclomol, which are orally administered molecular chaperone amplifiers.
Arimoclomol represents a novel approach to the treatment of CNS disorders by activating molecular chaperones that regulate the normal cellular protein repair pathway.
In the paper, "The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging - A Mini-Review," in the September 2009 edition of Gerontology (volume 55, pages 550-558), the authors found that molecular chaperone expression declines with aging, setting the stage for more interrogation of the role of molecular chaperone amplification in aging and longevity in human patients.
Hayer-Hartl's research focuses on the understanding of the mechanisms by which molecular chaperones mediate protein folding and inhibit misfolding in neurodegenerative diseases.
This volume consists of 21 chapters on molecular chaperones and the biological aspects of this family of proteins, as well as current research on protein folding in the endoplasmic reticulum (ER) and the functions of ER-resident molecular chaperones in protein folding of the ER.
KU-32 inhibits a specific member of a family of proteins called molecular chaperones.
While most molecular chaperones consume large amounts of cellular energy in order to function, HdeA instead taps energy freely available in its living environment.
Since damaged proteins called aggregates are thought to play a role in many diseases, CytRx believes that activation of molecular chaperones could have therapeutic efficacy for a broad range of diseases.
Those transcription factors in turn control other genes encoding molecular chaperones, whose job it is to protect all of a cell's proteins.
Since damaged proteins called aggregates are thought to play a role in many diseases, CytRx believes that activation of molecular chaperones with its drug candidates could demonstrate therapeutic efficacy over ALS as well as a broad range of additional diseases.

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