HSP90 defines a family of molecular chaperones
that are highly conserved from prokaryotes to eukaryotes.
A difference in the patterns of expression of the two heat-shock proteins is not surprising, as different molecular chaperones
perform different functions within a cell (Lindquist, 1986; Parsell and Lindquist, 1993).
2010) Induction of molecular chaperones
as a therapeutic strategy for the polyglutamine diseases.
In further support is the evidence that p26 does act as a molecular chaperone
The implication is if we can elevate the levels of this molecular chaperone
, we may be able to handle the situation a little better," Cashikar said.
Increased molecular chaperone
mRNA levels may be required in a particular tissue for signal transduction or osmolyte responses to intracellular ionic changes.
LOS ANGELES -- CytRx Corporation (Nasdaq: CYTR), a biopharmaceutical company specializing in oncology, today announced that it has sold the worldwide rights to its molecular chaperone
assets to privately-held, Copenhagen, Denmark-based Orphazyme ApS.
The concept that [Alpha]crystallin has a great variety of molecular chaperone
activities is supported by this study.
Recent studies have shown that Heat Shock Protein 90 (Hsp90), a molecular chaperone
that mediates maturation and activation of client proteins, plays a critical role in establishing resistance to radiation therapy.
To our knowledge, this is the first demonstration that inactivation of a specific molecular chaperone
from the mouse prostate epithelial cells can potently block prostate cancer development and suppress the activation of AKT, which is a protein kinase that promotes cell proliferation and survival and is a major factor in many types of cancer," she said.
CytRx currently has two orally administered, clinical-stage molecular chaperone
drug candidates and recently discovered a series of additional compounds that may provide a pipeline for additional drug candidates.
We are looking for opportunities to capitalize on the value of our molecular chaperone
assets to further support our oncology focus.