Mokola virus


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Mo·ko·la vi·rus

a rabies related virus of the genus Lyssavirus, family Rhabdoviridae, first isolated from shrews (Crocidura spp.) in Nigeria, which has caused fatal neurologic disease in humans and cats in Africa.

Mo·ko·la vi·rus

(mō-kō'lah vī'rŭs)
A rabies-related virus of the genus Lyssavirus, which has caused fatal neurologic disease.

Mokola virus

a rhabdovirus found in bats that has serological similarities to, but significant differences from, the rabies virus.
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We also tested for neutralizing antibodies against Lagos bat virus (LBV) and Mokola virus in 535 samples by using a modified rapid fluorescent focus inhibition test (10).
Until the AAHL researchers conducted their test, the classic rabies virus was thought to have just four close relatives: Lagos bat virus, Mokola virus, Duvenhage virus, and European bat virus.
Within the genus Lyssavirus, 12 species have been described: Rabies virus (RABV), Lagos bat virus (LBV), Mokola virus (MOKV), Duvenhage virus (DUVV), European bat lyssavirus types 1 and 2 (EBLV-1 and -2), Australian bat lyssavirus (ABLV), Aravan virus (ARAV), Khujand virus (KHUV), Irkut virus (IRKV), West Causasian bat virus (WCBV), and Shimoni bat virus (SHIBV).
Eleven Lyssavirus species have been classified: Rabies virus (RABV), Lagos bat virus (LBV), Mokola virus (MOKV), Duvenhage virus (DUVV), European bat lyssavirus types -1 and -2, Australian bat lyssavirus, Aravan virus, Khujand virus, Irkut virus, and West Caucasian bat virus (WCBV) (1).
The genus Lyssavirus within the family Rhabdoviridae contains 11 viruses: rabies virus (RABV), Lagos bat virus, Mokola virus, Duvenhage virus, European bat lyssaviruses types 1 and 2 (EBLV-1 and EBLV-2), Australian bat lyssavirus, Aravan virus (ARAV), Khujand virus (KHUV), Irkut virus, and West Caucasian bat virus (2).
Presently, 7 species are recognized within the genus Lyssavirus (order Mononegavirales, family Rhabdoviridae): Rabies virus (RABV), Lagos bat virus (LBV), Mokola virus (MOKV), Duvenhage virus (DUVV), European bat lyssavirus, types 1 and 2, and Australian bat lyssavirus.
The genus Lyssavirus is differentiated into 7 genetically divergent genotypes: classical rabies virus (genotype 1), Lagos bat virus (LBV; genotype 2), Mokola virus (MOKV; genotype 3), Duvenhage virus (genotype 4), European bat lyssavirus (genotypes 5 and 6), and Australian bat lyssavirus (genotype 7) (1).
Mokola virus (MOKV) is classified as genotype (gt) 3 of the genus Lyssavirus in the family Rhabdoviridae (order Mononegavirales).
Lagos bat virus (LBV) (gt2), Mokola virus (gt3), and Duvenhage virus (gt4) have been found only in Africa.
The genus Lyssavirus within the family Rhabdoviridae currently includes rabies virus (RABV) (genotype 1) and 6 rabies-related viruses: 3 from Africa, Lagos bat virus (LBV) (genotype 2), Mokola virus (MOKV) (genotype 3), and Duvenhage virus (DUVV) (genotype 4); European bat lyssaviruses 1 and 2 (EBEV1 and 2) (genotypes 5 and 6); and Australian bat lyssavirus (ABEV) (genotype 7) (1).
Of these, RABV (genotype 1) occurs worldwide, but LBV (genotype 2), Mokola virus (genotype 3), and Duvenhage virus (genotype 4) have not been encountered outside of Africa.
The Lyssavirus genus is differentiated into 7 genetically divergent lineages, Rabies virus (genotype 1), Lagos bat virus (genotype 2), Mokola virus (genotype 3), Duvenhage virus (genotype 4), EBLV-1 (genotype 5), EBLV-2 (genotype 6), and Australian bat lyssavirus (genotype 7).