mixed episode


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episode

 [ep´ĭ-sōd]
a single noteworthy happening in the course of a longer series of events, such as one critical period of several during a prolonged illness.
hypomanic episode a period of elevated, expansive, or irritable mood similar to a manic episode but not as severe; see also bipolar disorders and mood disorders.
major depressive episode a period of daily and day-long depressed mood or loss of interest or pleasure in virtually all activities. Also present is some combination of altered appetite, weight, or sleep patterns, psychomotor agitation or retardation, difficulty thinking or concentrating, lack of energy and fatigue, feelings of worthlessness, self-reproach, or inappropriate guilt, recurrent thoughts of death or suicide, and plans or attempts to commit suicide. See also bipolar disorders and mood disorders.
manic episode a period of predominantly elevated, expansive, or irritable mood accompanied by some of the following symptoms: inflated self-esteem, decreased need for sleep, talkativeness, flight of ideas, distractibility, hyperactivity, hypersexuality, and recklessness. See also bipolar disorders and mood disorders.
mixed episode a period during which the criteria are met both for a major depressive episode and for a manic episode nearly every day, with rapidly alternating moods and with symptoms characteristic of each type of episode. See also bipolar disorders and mood disorders.

mixed episode

1. a manifestation of a major mood disorder involving simultaneous symptoms of a manic episode and a major depressive episode.
2. a DSM construct when specified criteria are met.
A period of 1 week in which the diagnostic criteria for manic and depressive episodes are met on nearly every day, with abrupt mood swings from sadness to irritability to euphoria

mixed episode

Psychiatry A period of ≥ 1 wk in which criteria for manic and depressive episodes are met on nearly every day, with abrupt mood swings from sadness, irritability, euphoria Clinical Agitation, insomnia, appetite dysregulation, psychotic features and suicidal ideation; MEs are of sufficient severity to cause impairment of social and occupational function and/or require hospitalization. See Bipolar disorder.

mix·ed ep·i·sode

(mikst epi-sōd)
Sign of a major mood disorder involving simultaneous symptoms of manic and major depressive episodes.
See: bipolar disorder, manic episode, major depressive disorder

mix·ed ep·i·sode

(mikst epi-sōd)
Manifestation of major mood disorder involving simultaneous symptoms of a manic episode and a major depressive episode.
References in periodicals archive ?
One study of patients meeting criteria for DSM-IV-TR mixed episodes evaluated a mood stabilizer alone versus a mood stabilizer combined with an atypical antipsychotic.
26) Asenapine is provided in a rapidly absorbed, sublingual form and is FDA-approved for treating acute mania or mixed episodes associated with BDI.
Mixed episodes may be difficult to identify, particularly when a clinician has not seen them before or when the patient's symptoms only partially meet the criteria for a mixed episode.
Acute treatment of manic or mixed episodes associated with Bipolar I Disorder as monotherapy and as an adjunct to lithium or valproate for adults and pediatrics 10 to 17 years of age
Details of the 5 industry-sponsored RCTs of atypical antipsychotics in children and adolescents with bipolar I manic or mixed episodes are summarized in Table 1 (page 24).
As there are many medications with indications for mania, a good choice is to start with a medication that has a specific indication for mixed episodes, namely, aripiprazole, carbamazepine extended release, divalproex extended release, olanzapine, risperidone, or ziprasidone (See TABLE).
The subjects also had a history of one or more manic or mixed episodes that had been severe enough to require hospitalization and / or treatment with a mood stabilizer or antipsychotic.
The course of bipolar II disorder is usually dominated by depressive episodes and symptoms with only brief periods of hypomania (by definition, frank manic or mixed episodes occur in bipolar I disorder; only hypomanic or milder manic and mixed episodes occur in bipolar II illness).
Risperidone's efficacy for short-term treatment of mania in children and adolescents was demonstrated in a 3-week, randomized, double-blind, placebo-controlled, multi-center study of 169 patients age 10 to 17 who were experiencing a manic or mixed episode of bipolar I disorder.
The study involved 238 bipolar I patients aged 6-17 years with a manic or mixed episode who were randomized 2:1 to ziprasidone (Geodon) at 60-160 mg/day or placebo at 36 US.
Because a mixed episode can include elements of depression, and because the manic aspect of the episode may be characterized more by restless energy and irritability than by pure mania, it can be difficult to distinguish a mixed state from a simple depressive episode.