mixed connective tissue disease


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Related to mixed connective tissue disease: polymyositis, Undifferentiated Connective Tissue Disease

mixed connective tissue disease

 
a combination of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis, and marked serologically by the presence of antibody against extractable nuclear antigen.

mixed connective tissue disease (MCTD)

a systemic disease characterized by the combined symptoms of various collagen diseases, such as synovitis, polymyositis, scleroderma, and systemic lupus erythematosus, with a high concentration of antibodies of ribonucleoprotein. Other symptoms may include arthralgia, muscle inflammation, nondeforming arthritis, swollen hands, esophageal hypomotility, and reduced diffusing capacity of the lungs. Treatment often includes the administration of corticosteroids. Recurrence is common when the steroid medication is discontinued.
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Mixed connective tissue disease

mixed connective tissue disease

A connective tissue disease with features of SLE, dermatomyositis, rheumatoid arthritis Clinical Pleuritis, Raynaud's phenomenon, sclerodactyly, good response to steroids Lab MCTD has a unique speckled nucleolar pattern due to presence of a specific circulating antibodies to ribonucleoprotein; no antibodies to double-stranded DNA and Sm antigen. See Antinuclear antibodies, 'Chinese menu' diseases, Overlap syndrome.

mix·ed con·nec·tive tis·sue dis·ease

(mikst kŏ-nek'tiv tish'ū di-zēz')
Disorder with overlapping features of various systemic connective-tissue diseases and with serum antibodies to nuclear ribonucleoprotein.

mixed connective tissue disease

A condition that combines some of the features of SYSTEMIC LUPUS ERYTHEMATOSUS, POLYMYOSITIS and progressive SYSTEMIC SCLEROSIS. The blood contains high levels of ANTINUCLEAR ANTIBODY. There are skin changes similar to DERMATOMYOSITIS, swelling of the fingers with RAYNAUD'S phenomenon, muscle weakness and arthritis involving several joints. The condition responds well to treatment with corticosteroid drugs and the outlook is favourable.
References in periodicals archive ?
Comparative study of 4 diagnosis criteria sets for mixed connective tissue disease in patients with anti-RNP antibodies, autoimmunity group of the hospitals of toulouse.
Isolated pulmonary capillaritis and diffuse alveolar hemorrhage in rheumatoid arthritis and mixed connective tissue disease.
Anticentromere antibodies are seen in 20%-30% of scleroderma patients and are the most predictive of risk to progression to limited systemic sclerosis, although they are also commonly seen in primary biliary cirrhosis and, rarely, in other connective tissue diseases, such as rheumatoid arthritis, systemic lupus erythematosus, mixed connective tissue disease, and polymyositis, he said.
not Sjogren syndrome and/or any form of lupus, mixed connective tissue disease, dermatomyositis, scleroderma, or rheumatoid arthritis).
Autoantibodies to Sm are found in 30- 40% of patients with SLE, while autoantibodies to Sm/RNP may be found in patients with SLE, Sjsgrens Syndrome, primary systemic sclerosis (scleroderma), or mixed connective tissue disease.
Outcome of pregnancies complicated by systemic sclerosis and mixed connective tissue disease.
Anti-SSA and anti-SSB antibodies are found in Sjogren Syndrome (SS), anti-Sm antibodies are found in systemic lupus erythematosus (SLE), anti-RNP antibodies are found in mixed connective tissue disease (MCTD), and anti-Scl-70 antibodies are found in scleroderma.