mixed connective tissue disease


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Related to mixed connective tissue disease: polymyositis, Undifferentiated Connective Tissue Disease

mixed connective tissue disease

 
a combination of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis, and marked serologically by the presence of antibody against extractable nuclear antigen.

mixed connective tissue disease (MCTD)

a systemic disease characterized by the combined symptoms of various collagen diseases, such as synovitis, polymyositis, scleroderma, and systemic lupus erythematosus, with a high concentration of antibodies of ribonucleoprotein. Other symptoms may include arthralgia, muscle inflammation, nondeforming arthritis, swollen hands, esophageal hypomotility, and reduced diffusing capacity of the lungs. Treatment often includes the administration of corticosteroids. Recurrence is common when the steroid medication is discontinued.
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Mixed connective tissue disease

mixed connective tissue disease

A connective tissue disease with features of SLE, dermatomyositis, rheumatoid arthritis Clinical Pleuritis, Raynaud's phenomenon, sclerodactyly, good response to steroids Lab MCTD has a unique speckled nucleolar pattern due to presence of a specific circulating antibodies to ribonucleoprotein; no antibodies to double-stranded DNA and Sm antigen. See Antinuclear antibodies, 'Chinese menu' diseases, Overlap syndrome.

mix·ed con·nec·tive tis·sue dis·ease

(mikst kŏ-nek'tiv tish'ū di-zēz')
Disorder with overlapping features of various systemic connective-tissue diseases and with serum antibodies to nuclear ribonucleoprotein.

mixed connective tissue disease

A condition that combines some of the features of SYSTEMIC LUPUS ERYTHEMATOSUS, POLYMYOSITIS and progressive SYSTEMIC SCLEROSIS. The blood contains high levels of ANTINUCLEAR ANTIBODY. There are skin changes similar to DERMATOMYOSITIS, swelling of the fingers with RAYNAUD'S phenomenon, muscle weakness and arthritis involving several joints. The condition responds well to treatment with corticosteroid drugs and the outlook is favourable.
References in periodicals archive ?
Anti-Ro/SS-A and anti-La/SS-B antibodies recognize cellular proteins complexed with small nuclear RNAs, and are found mainly in association with Sjogren syndrome and SLE, although they can be found in other conditions such as scleroderma, polymyositis, mixed connective tissue disease, and rheumatoid arthritis.
The most common systemic autoimmune diseases are systemic lupus erythematosus, Sjogren's syndrome, scleroderma, rheumatoid arthritis, autoimmune vasculitis, and mixed connective tissue disease.
110) Mixed connective tissue disease is the term used for patients exhibiting features of SLE, PSS, DM, or PM, and having anti-(U1)snRNP antibodies.
Huston's group, 122 of 791 patients with scleroderma and mixed connective tissue disease who were seen in 50 community rheumatology practices had an existing diagnosis of PAH.
Mixed connective tissue disease was diagnosed according to the criteria proposed by Alarcon-Segovia et al.