mitogen

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Related to Mitogens: mitogenesis

mitogen

 [mi´to-jen]
a substance that induces blast transformation; DNA, RNA, and protein synthesis; and proliferation of lymphocytes; e.g., concanavalin A, phytohemagglutinin, or lipopolysaccharide.

mi·to·gen

(mī'tō-jen),
A substance frequently derived from plants that stimulates mitosis and lymphocyte transformation in an antigen-nonspecific manner; includes not only lectins such as phytohemagglutinins, pokeweed mitogen, and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.
Synonym(s): transforming agent (1)
[mitosis + G. -gen, producing]

mitogen

/mi·to·gen/ (mīt″o-jen) a substance that induces mitosis and cell tranformation, especially lymphocyte transformation.mitogen´ic

mitogen

(mī′tə-jən)
n.
An agent that induces mitosis.

mi′to·gen′ic (mī′tə-jĕn′ĭk, mĭt′ə-) adj.
mi′to·ge·nic′i·ty (-jə-nĭs′ĭ-tē) n.

mitogen

[mī′təjən, mit′-]
Etymology: Gk, mitos + genein, to produce
an agent that triggers mitosis. mitogenic, adj.

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.

mitogen

1. Any agent that promotes cell nuclear division (MITOSIS). Mitogens are important in genetic research and technology. Pokeweed mitogen, derived from the plant Phytolacca americana , is a powerful mitogen of B LYMPHOCYTES.
2. Any substance that non-specifically causes lymphocytes to proliferate.

mitogen

a growth factor in the form of a small protein found in blood serum that often has a specific target organ in which it induces MITOSIS.

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci and from strains of α-toxin-producing staphylococci.

mitogen,

n an agent that triggers mitosis.

mitogen

an agent that induces mitosis and lymphocyte blastogenesis.

pokeweed mitogen (PWM)
a lectin from the plant, Phytolacca americana, that produces B and T lymphocyte blastogenesis.
References in periodicals archive ?
Mitogen stimulated lymphocyte proliferation was significantly increased compared to control without mitogen stimulation (p <0.
6,15,26) Generated ROS, especially hydrogen peroxide, followed by mitogen stimulation of the T lymphocyte, function as a second messenger to signal T cell activation.
b) Catalog numbers for mitogens purchased from Sigma are shown in parentheses; PHA was purchased from Amersham Pharmacia Biotech.
Non-DMSO controls, DMSO controls, and each contaminant concentration were tested in triplicate with and without mitogen stimulation for each turtle.
Keywords: Astragalus corniculatus; Saponins; Graffi myeloid tumor; Mitogen response; Spleen lymphocytes; PHA; LPS
Stimulation index (SI) of lymphocytes was calculated according to the formula: SI = number of cpm of lymphocytes incubated with mitogen: number of cpm of lymphocytes incubated without mitogen.
We believe this factor is CM because preparations of this mitogen directly stimulated PC-3 cells in vitro as well.
Regardless of its mechanism of action, the present in vitro and in vivo studies demonstrate that the corncob bedding-derived factor (CM) is an active mitogen in ER-positive and ER-negative breast cancer cells and androgen-independent PC-3 human prostatic cancer cells.
Aberdeen Comparison mean [+ or -] SD mean [+ or -] SD Mitogens (n= 131) (n = 129) PHA Crude 131,710 [+ or -] 38,583 133,563 [+ or -] 38,274 Adjusted(b) 128,530 [+ or -] 3,197(c) 136,792 [+ or -] 3,223(c) CON-A Crude 67,025 [+ or -] 23,716 71,508 [+ or -] 24,636 Adjusted(b) 65,776 [+ or -] 2,108(c) 72,776 [+ or -] 2,126(c) PWM Crude 34,714 [+ or -] 20,845 39,930 [+ or -] 22,063 Adjusted(b) 33,068 [+ or -] 1,878(c) 41,601 [+ or -] 1,893(c) Reference Mitogens p-Value ranges(a) PHA Crude 0.
As would be expected in a normal population, the results of the mitogen stimulation assays with the three different mitogens were highly correlated with one another: (PHA/CON-A, r = 0.
The murine splenocytes were used to assess lymphocyte proliferation response after mitogen stimulating for 20h.
After mitogen stimulation of the spleen cells, 20 [micro]l/well of tetrazolium salt MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide, Siga, St.