mitogen-activated protein kinase

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MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.

mitogen-activated protein kinase



A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
References in periodicals archive ?
To determine whether the phosphorylation of mitogen-activated protein kinases (MAPKs) plays a key role in parvifloron D-induced cell death, we examined the effects of specific inhibitors.
The traditional cytoplasmic EGFR-initiated route involves transduction of mitogenic signals through activation of several signaling cascades, such as phospholipase C[gamma], protein kinase C, mitogen-activated protein kinases, phosphatidyl i nositol-3-kinase, and signal transducer and activator of transcription (STATs) (Bae et al.
Early weaning increases intestinal permeability, alters expression of cytokine and tight junction proteins, and activates mitogen-activated protein kinases in pigs.
Discussion encompasses climate change and food security, genetic engineering for acid soil tolerance in plants, mitogen-activated protein kinases in abiotic stress tolerance in crop plants, and the roles of plant viruses (maybe they're not always villains), as well as the specifics of rice, pearl millet, bamboo, groundnuts, and chickpeas, among other topics.
ERK 1/2, which are also known as classical mitogen-activated protein kinases (MAPKs), were found to be increased in the RPE of human eyes with GA and shown to be key mediators of RPE cell death.
Probiotics modulate host cell signaling pathways, including Akt, mitogen-activated protein kinases, and nuclear factor-kappaB to mediate these intestinal epithelial functions.
Watts and his team discovered that enzymes known as mitogen-activated protein kinases form a critical link between changes in blood glucose levels, certain neurons in the hypothalamus, and the release of glucose-control ling hormones.
Among their topics are myth and science regarding laser and light therapy for acne, emerging trends in the diagnosis and management of atopic dermatitis, which side mitogen-activated protein kinases and their inhibitors are on in the fight against psoriasis, dendritic cell immunotherapy for treating malignant melanoma, malignant melanoma in ethnic skin, a novel transdermal drug delivery system mediated by arginine-rich intracellular delivery peptides, and onychomysosis caused by non-dermatophytic filamentous fungi.
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.
Protein tyrosine kinases (PTK) and mitogen-activated protein kinases (MAPK) are other important additional or alternative signalling elements of the signal transduction cascade responsible for APC.
Pacific Session: Interstitial Lung Disease 1 -- Slide Presentation (#3961): The Combination of Interferon Gamma-1b and Pirfenidone Inhibits Transforming Growth Factor-Beta-Induced Gene Induction in Cellular Models of Lung Fibrosis -- Slide Presentation (#4467): Pirfenidone Attenuates Transforming Growth Factor-Beta-Induced Activation of p38-Alpha and p38-Gamma Mitogen-Activated Protein Kinases in Human Lung Fibroblasts: Implications for Treatment of Fibrotic Lung Diseases InterMune researchers will also make the following presentations at CHEST: Tuesday, October 24, 2006 -- 10:30 a.

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